摘要
目的 :研究血液中凝血因子 ,尿激酶型纤溶酶原激活物 ( UPA)和抑制物 - 1( PAI- 1)水平对恶性肿瘤的影响。方法 :F a采用重组可溶性组织因子 ( r STF)一期法 ,F :C采用经典一期法 ,F :Ag、U PA和 PAI- 1采用 EL ISA法测定。结果 :1肿瘤组 F :Ag、F a、UPA和 PAI- 1较对照组显著升高 ( P <0 .0 1～ 0 .0 0 1)。 2中、晚期肿瘤组 F a、U PA较早期组升高 ;已转移组 F a、UPA和 PAI- 1较未转移组高 ;死亡组全部指标较存活组显著升高 ( P<0 .0 5～ 0 .0 1)。 3F a与 U PA、PAI- 1水平呈正相关。结论 :恶性肿瘤患者血液中 F :Ag、F a、U PA和 PAI- 1显著升高 。
Objective:To study the level of plasma coagulation FⅦ, UPA and PAI 1 in patients of malignant tumor.Methods:FⅦa was determinated by one phase clotting method using recombinant soluble tissue fator (rSTF). FⅦ:C was determnated by classic one phase clotting method, FⅦ:Ag, UPA and PAI 1 were method by ELISA.Results:①FⅦ:Ag, FⅦa,UPA and PAI 1 level in malignent tumor patients were higher than those in normal group (P< 0.01 ～ 0.001 ). ②FⅦa、UPA level in malignent tumor patients of median and later period were higher than early period.FⅦa,UPA and PAI 1 in metastasied group were higher than unmetastasized group.These four indexs n death group were higher than survived group (P< 0.05 ～ 0.01 ).③FⅦa level positively correlated with UPA and PAI 1 level in tumor group.Conclusion:The plasma level of FⅦ:Ag,FⅦa, UPA and PAI 1 in patients of malignance tumor have a significant rise than normal subjects.The latter three indexs are independent risk factors of tumor deteriorating and metastasis.
出处
《临床血液学杂志》
CAS
2000年第3期102-104,共3页
Journal of Clinical Hematology
