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miRNA在结直肠癌发生发展过程中的调控机制 被引量：6

Mechanism of miRNA in regulating carcinogenesis of colorectal cancer
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摘要 内源的功能性非编码小分子RNA-miRNA,在转录后水平调控目的基因的表达,进而参与调节细胞周期、凋亡、分化、发育以及肿瘤发生等多种生物学过程。miRNA能够调节DNA甲基化修饰,并对许多结直肠癌相关重要信号通路具有调控作用。miRNA表达异常会引起WNT、EGFR通路过度激活,TGFβ信号响应缺失,以及p53等抑癌基因的失活,导致结直肠癌发生。miRNA的甲基化修饰及其与靶基因的单核苷酸多态性(SNP)是miRNA调控结直肠癌发生的重要分子机理。本文总结了miRNA在结直肠癌发生发展过程中的调控作用及其分子机制,并初步探讨了miRNA表达异常致使肿瘤发生的影响因素。
作者 刘林 聂晶 郑伟 田文 杜晓辉
机构地区 解放军总医院普通外科 解放军总医院基础医学所分子生物研究室
出处 《军医进修学院学报》 CAS 2012年第5期542-544,共3页 Academic Journal of Pla Postgraduate Medical School
基金 国家公益卫生行业科研课题(200702012) 国家自然科学基金项目(31100554)~~
关键词 MIRNA 结直肠癌 甲基化 SNP
分类号 R730.2 [医药卫生—肿瘤]
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参考文献26

  • 1Wu WK,Law PT,Lee CW. MicroRNA in colorectal cancer:from benchtop to bedside[J].Carcinogenesis,2011,(03):247-253.
  • 2Jemal A,Siegel R,Ward E. Cancer statistics,2009[J].CA:A Cancer Journal for Clinicians,2009,(04):225-249.doi:10.3322/caac.20006.
  • 3Michael MZ,O' Connor SM,van Hoist Pellekaan NG. Reduced accumulation of specific microRNAs in colorectal neoplasia[J].Molecular Cancer Research,2003,(12):882-891.
  • 4Cunningham D,Atkin W,Lenz HJ. Colorectal cancer[J].The Lancet,2010,(9719):1030-1047.
  • 5Nagel R,le Sage C,Diosdado B. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer[J].Cancer Research,2008,(14):5795-5802.
  • 6Chen X,Guo X,Zhang H. Role of miR-143 targeting KRAS in colorectal tumorigenesis[J].Oncogene,2009,(10):1385-1392.doi:10.1038/onc.2008.474.
  • 7Tsang WP,Kwok TT. The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras[J].Carcinogenesis,2009,(06):953-959.doi:10.1093/carcin/bgp094.
  • 8Akao Y,Nakagawa Y,Hirata I. Role of anti-oncomirs miR-143 and-145 in human colorectal tumors[J].Cancer Gene Therapy,2010,(06):398-408.doi:10.1038/cgt.2009.88.
  • 9Kulda V,Pesta M,Topolcan O. Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases[J].Cancer Genetics and Cytogenetics,2010,(02):154-160.
  • 10Guo C,Sah JF,Beard L. The noncoding RNA,miR-126,suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers[J].Genes,Chromosomes and Cancer,2008,(11):939-946.doi:10.1002/gcc.20596.

同被引文献78

  • 1姚云峰.结直肠癌的TNM分期[J].中国医学前沿杂志（电子版）,2011,3(6):8-10. 被引量：31
  • 2Tavazoie SF, Alarcon C , Oskarsson T, et al. Endogenous humanmicroRNAs that suppress breast cancer metastasis [ J]. Nature,2008, 451 (7175) :147 -152.
  • 3WU W K, LAW P T, LEE C W, et al. MicroRNA in colorectal cancer: from benchtop to bedside[J]. Carci- nogenesis, 2011,32 : 247- 253.
  • 4LINK A, BALAGUER F, SHEN Y, et al. Fecal Mi- croRNAs as novel biomarkers for colon cancer screen- ing[J]. Cancer Epidermiol Biomarkers Prev, 2010, 19: 1766-1774.
  • 5WANG C J, ZHOU Z G, WANG L, et al. Clinicopatho- logical significance of microRNA-31 <143 and -145 ex- pression in colorectal cancer[J]. Dis Markers, 2009,26: 27-34.
  • 6NG E K,TSANG W P, NG S S, et al. MicroRNA-143 targets DNA methyltransferases 3A in colorectal canc er[J]. Br J Cancer, 2009,101 : 699- 706.
  • 7SLABY O, SVOBODA M, FABIAN P, et al. Altered expression of miR-21, miR-31,miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer[J]. Oncology, 2007,72 : 397-402.
  • 8XU T, ZHU Y, XlONG Y, et al. MicroRNA-195 sup- presses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells[J]. Hepatology, 2009,50:113-121.
  • 9Lehwald N,Tao GZ,Jang KY,et al.β-Catenin regulates hepatic mitochondrial function and energy balance in mice[J].Gastroenterology,2012,143 (3):754-764.
  • 10Cawthorn WP,Bree AJ,Yao Y,et al.Wnt6,Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism[J].Bone,2012,50 (2):477-489.

引证文献6

二级引证文献41

军医进修学院学报
2012年 第5期

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