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细菌内毒素检测方法的研究进展 被引量:2

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摘要 19世纪,Pfeiffer首先提出“内毒素”一词,是指革兰阴性细菌培养滤液中具有生物活性的热稳定物质。后来几十年的化学研究表明,内毒素的主要成分是脂多糖(lipopolysaccharidle,LPS),多存在于革兰阴性杆菌和球菌细胞壁中,是一个复杂的大分子,含有与多糖共价结合的脂类,即类脂A。类脂A是LPS的“毒力中心”,在生物活性中起关键作用。内毒素是许多疾病的病因,其中败血性休克最为常见。由于侵袭性医疗程序和免疫抑制剂应用的增多。
作者 胡金川
机构地区 解放军第
出处 《医学综述》 2000年第5期222-224,共3页 Medical Recapitulate
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参考文献1

  • 1丁振若,崔桂,孙怡群,魏建勤.鲎试验检测内毒素几种方法的比较[J]第四军医大学学报,1986(02).

同被引文献28

  • 1王莉,高华,蔡彤,张国来,季晖.鲎试剂的研究及应用进展[J].药物分析杂志,2007,27(6):938-942. 被引量:13
  • 2Morrison DC,Ulevitch RJ. The effects of bacterial endotoxins on host mediation systems. A review. Am J Pathol, 1978, 93(2): 526-618.
  • 3Raetz CR, Whitfield C. Lipopolysaccharide endotoxins. Annu Rev Biochem, 2002, 71: 635-700.
  • 4Levin J,Bang FB. The role of endotoxin in the extracellular coagulation of limulus blood. Bull Johns Hopkins Hosp, 1964, 115: 265-274.
  • 5Nakamura T, Tokunaga F, Morita T, et al. IntraceUular serine-protease zymogen, Factor-C, from horseshoe-crab hemocytes-its activation by synthetic lipid-a analogs and acidic phospholipids. Eur J Biochem,1988, 176(1): 89-94.
  • 6Tokunaga F, Miyata T, Nakamura T, et al. Lipopolysaccharide-sensitive serine-protease zymogen (factor C) of horseshoe crab hemocytes. Identification and alignment of proteolytic fragments produced during the activation show that it is a novel type of serine protease. Eur J Biochem, 1987, 167(3): 405-416.
  • 7Pui AWM, Ho B, Ding JL. Yeast recombinant Factor C from horseshoe crab binds endotoxin and causes bacteriostasis. J Endotoxin Res, 1997, 4(6): 391-400.
  • 8Roopashree SD, Chai C, Ho B, et al. Expression of Carcinoscorpius rotundicauda factor C cDNA.Biochem Mol Biol Int, 1995, 35(4): 841-849.
  • 9Roopashree SD, Ho B, Ding JL. Expression of Carcinoscorpius rotundicauda Factor C in Pichia pastoris. Mol Mar Biol Biotechnol, 1996, 5(4): 334-343.
  • 10Wang J, Ho B, Ding JL. Functional expression of full length limulus Factor C in stably transformed Sf9 cells. Biotechnol Lett, 2001, 23(1): 71-76.

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