摘要
目的观察相同剂量低分子肝素联合不同剂量阿司匹林肠溶片治疗急性脑梗死的临床疗效和安全性。方法将急性脑梗死患者80例随机分为对照组和治疗组各40例。2组低分子肝素用量相同,5 000U腹部皮下注射,2次/d,连用2周。对照组阿司匹林100mg口服,1次/d,连用2周,治疗组阿司匹林300mg口服,1次/d,连用2周。2周后观察2组治疗前后神经功能缺损评分、临床疗效及凝血功能变化。结果与对照组相比,治疗组治疗后神经功能缺损评分明显降低,临床有效率显著提高,差异有统计学意义(P<0.05),而治疗前后凝血功能差异无统汁学意义(P>0.05)。结论在脑梗死急性期,低分子肝素同等条件下,阿司匹林肠溶片300mg/d临床疗效优于100mg/d。
Objective To observe the clinical effect and safety of same dose of low molecular weight heparin in combination with different doses of enteric - coated aspirin tablet in the treatment of acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly divided into control group and treatment group with 40 cases in each group. The same dose of low molecular weight heparin was used in two groups, 5 000 U injected subcutaneously, twice daily for 2 weeks. In control group,aspirin 100 mg was given orally once a day was given orally once a day for 2 weeks. Neurological function changes were observed before and 2 weeks after for 2 weeks. In treatment group, aspirin 300 mg deficit score, clinical efficacy and coagulation treatment. Results Compared with the control group, neurological deficit score in treatment group was significantly lower and clinical efficiency significantly increased, the difference was statistically significant （P 〈 0.05 ）, and there was no significant difference in coagulation function before and after treatment （ P 〉 0.05 ）. Conclusion With the same dose of low molecular weight heparin, enteric - coated aspirin tablets at 300 mg/d is superior to 100mg/d used in improving clinical efficacy of acute cerebral infarction.
出处
《河北医科大学学报》
CAS
2012年第2期139-141,共3页
Journal of Hebei Medical University
关键词
肝素
低分子量
阿司匹林
脑梗塞
heparin, low - molecular - weight
aspirin
brain irffarction
