摘要
目的观察辛伐他汀治疗不稳定型心绞痛的临床疗效。方法将102例不稳定型心绞痛患者随机分为对照组(51例)和治疗组(51例),对照组给予阿司匹林、低分子肝素、硝酸酯类药物、β受体阻滞剂、血管紧张素转换酶抑制剂、钙离子拮抗剂等常规治疗,治疗组在常规治疗基础上加用辛伐他汀20 mg/d、睡前口服,疗程8周。观察两组患者的临床疗效和心电图变化。结果治疗后,治疗组临床心绞痛及心电图疗效明显优于对照组(P<0.05),两组均无明显不良反应发生。结论辛伐他汀治疗不稳定型心绞痛疗效确切,且用药安全。
Objective To observe the clinical curative effects and the safety of simvastatin in the treatment of unstable angina pectoris. Methods A hundred and two cases of unstable angina pectoris were randomly divided into the control group （51 cases） and the treatment group （51 cases）. The control group was given the basic treatment such as aspirin, low molecular weight heparin, ester nitrate, angiotensin converting enzyme inhibitors（ACEIs） and calcium ion antagonist. On the basis of basic treatment, the treatment group was added simvastatin 20 mg/d for 8 weeks. The clinical curative effects and the electrocardiogram（ECG） change were observed in the two groups. Results After 3- month treatment, the curative effects of clinical angina pectoris and ECG in the treatment group were signifi- cantly superior to the control group （P 〈 0.05）. No obvious adverse reactions occurred in the two groups. Conclusion Simvastatin is definitely effective to treat unstable angina pectoris with safe medication.
出处
《中国药业》
CAS
2012年第7期76-77,共2页
China Pharmaceuticals
关键词
辛伐他汀
心绞痛
疗效
simvastatin
angina pectoris
treatment
