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Th_(17)细胞及IL-17与消化系统肿瘤 被引量：1

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摘要 1986年，Mosmann和Coffman根据所分泌细胞因子的不同将CD；T细胞分为Th1和Th2两个亚型，Th1分泌效应因子干扰素（IFN）-γ，Th2主要分泌IL-4。20多年来关于Th1和Th2细胞功能的研究形成了对免疫生物学、固有免疫及免疫调节认识的框架。2005年，
作者 孟欣颖 周长宏
机构地区 青岛市立医院干部保健科
出处 《中国医刊》 CAS 2012年第4期29-31,共3页 Chinese Journal of Medicine
关键词 Th17细胞 消化系统肿瘤 IL-17 干扰素(IFN)-Γ 分泌细胞因子 免疫生物学 TH2 效应因子
分类号 R573 [医药卫生—消化系统]
  • 相关文献

参考文献24

  • 1Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties[ J ]. Annu Rev Immunol, 1989, 7:145 - 173.
  • 2Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 [ J]. Nat Immunol, 2005, 6:1133 - 1141.
  • 3Mangan PR, Harrington LE, O' Qninn DB, et al. Transforming growth factor beta induces development of the T(H) 17 lineage[ J]. Nature, 2006, 441 : 231 - 234.
  • 4Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, et al. Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells [ J]. Nat Immunol, 2007, 8:942 - 949.
  • 5Manel N, Unutmaz D, Littman DR. 31ae differentiation of human T ( H)- 17 cells requires transforming growth factorbeta and induction of the nuclear receptor RORgammat[J]. Nat Immunol, 2008, 9:641 -649.
  • 6Yang L, Anderson DE, Baecher-Allan C, et al. IL-21 and TGFbeta are required for differentiation of human T(H) 17 cells[J]. Nature, 2008, 454:350 -352.
  • 7Miyahara Y, Odunsi K, Chert W, et al. Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer[ J]. Proc Natl Acad Sci USA, 2008, 105:15505 -15510.
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  • 9Yang XO, Panopoulos AD, Nurieva R, et al. STAT3 regulates cytokinemediated generation of inflammatory helper T cells [ J ]. J Biol Chem. 2007. 282:9358-9363.
  • 10Chen Q, Yang W, Gupta S, et al. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor[ J ]. Immunity, 2008, 29:899 - 911.

二级参考文献11

  • 1李岩,梁婧,刘文波,许晓群,赵跃然.化疗对胃癌Th1和Th2类细胞因子漂移的影响及临床意义[J].中华肿瘤杂志,2004,26(12):732-734. 被引量：20
  • 2杨文锋,于金明,左文述,王善政.食管癌组织中共刺激分子与白介素-10 mRNA的表达[J].中华肿瘤杂志,2006,28(10):762-765. 被引量：9
  • 3Kryczek I,Wei S,Zou L,et al.Cutting edge:Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment J Immunol.2007.178:6730-6733.
  • 4Sfanos KS,Bruno TC,Maris CH,et al.Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.Clin Cancer Res.2008,14:3254-3261.
  • 5Mudda D,Park Y,Kim G,et al.Reciprocal THl7 and regulatoryy T cell diffentiation mediated by retlnoic acid.Science,2007,317:256-260.
  • 6Acosta-Rodiguez EV,Napolitari G,Lanzavecchia A,et al.Intedeukins lbeta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.Nat Immunol.2007.8:942-949.
  • 7Manel N,Unutmaz D,Littman DR.The differentiation of human T_H-17 cells requires transforming tooth factor-β and induction of the nuclear receptor RORγT.Nat Immunol,2008,9:641-649.
  • 8Veldhcen M,Hocking RJ,Atkins CJ,et al.TGFbeta in the context of an inflanmmtory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity,2006,24:179-189.
  • 9Bmley sL,Schrelner B,McMahon EJ,et al.CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+T(H)-17 cells in relapsing EAE.Nat Immunol,2007,8:172-180.
  • 10Yang XO,Nurieva R,Martinez CJ,et al.Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.Immunity.2008.29:44-56.

共引文献24

同被引文献14

  • 1Bettell E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH 17 and regulatory T cells[J]. Nature, 2006, 44 i (7090):235-238.
  • 2Liaw YF: Natural history of chronic hepatitis B virus infection and long-term outcome under treatment[J]. Liver Int, 2009, 29(1):100-107.
  • 3Rong G, Zhou Y, Xiong Y, et al. Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripHeral cell population[J]. Clin Exp Immunol, 2009, 156(2):217-225.
  • 4Opden Brouw ML, Binda RS, van Roosmalen MH, et al. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus[J]. Immunology, 2009, 126(2):280-289.
  • 5Langrish CL, Chen Y, Blumensehein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflam- mation[J]. J Exp Med, 2005, 201(2):233-240.
  • 6Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity[J]. Nat Immun01, 2007, 8(4): 345-350.
  • 7Wu W, Li J, Chen F, et al. Circulating Thl7 cells frequency is associated with the disease progression in HBV infected patients[J]. J Gastroenterol Hepatloy, 2010, 25(4):750-757.
  • 8赵燕,沈立松.TGF-β在CD4^+CD25^+调节性T细胞和Th17细胞分化中的调控[J].现代免疫学,2011,31(2):156-159. 被引量：6
  • 9陈捷,王兰兰,付阳,罗俐梅,廖云,李思阅,蔡蓓,李壹.IL-17、IL-23、TGF-β和IL-10在乙型肝炎病毒感染中的表达分析[J].免疫学杂志,2012,28(3):231-236. 被引量：36
  • 10王静,高伟,安选,钟卿,胡怀东,胡鹏,任红.Th17与Treg细胞免疫失衡在慢性乙型病毒性肝炎发病过程中的调节作用[J].西南大学学报（自然科学版）,2012,34(6):45-49. 被引量：9

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中国医刊
2012年 第4期

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