摘要
目的探讨不同剂量甘露醇对缺血性脑梗死患者血浆渗透压及肾功能的影响。方法将120例急性大面积脑梗死患者随机分为观察组和对照组,观察组患者应用20%甘露醇125ml/次,对照组患者应用20%甘露醇250mL/次。结果①观察组患者和对照组患者平均神志转清时间分别为(6.4±1.2)d和(6.3±1.1)d,平均视乳头水肿消退时间分别为(8.5±1.6)d和(8.3±1.7)d,两组间均无统计学差异(P>0.05)。②与治疗前相比,两组患者治疗后5d血浆渗透压、尿素氮及肌酐均有明显增高(P<0.05)。治疗后5d,观察组患者血液尿素氮和肌酐水平均明显低于对照组(P<0.05)。结论小剂量甘露醇降低缺血性脑梗死患者颅内压疗效肯定,而且对肾功能影响较小。
Objective To investigate the affect of different doses mannitol on plasma osmolality and renal function in patients with ischemic stroke.Methods 120 patients with acute massive cerebral infarction were randomly divided into two groups,the observation group were treated with 20% mannitol 125ml each time,while the control were treated with 20% mannitol 250ml each time.Results ①The average time of consciousness turned clear were（6.4 ± 1.2） days and（6.3 ± 1.1） days,the average time of optic disc edema were（8.5 ± 1.6） days and（8.3 ± 1.7） days,there were no statistically different（P 0.05）.②Compared with before,the plasma osmolality,urea nitrogen and creatinine were significantly higher after 5 days treatment（P0.05）.After 5 days treatment,blood urea nitrogen and creatinine of the observation group were significantly lower than the control（P0.05）.Conclusion Low dose mannitol can effectively reduces intracranial pressure in patients with ischemic stroke,and has less impact on renal function.
出处
《中国医药指南》
2012年第8期371-372,共2页
Guide of China Medicine
关键词
甘露醇
脑梗死
剂量
肾功能
Mannitol
Infarction
Dose
Renal function
