摘要
目的探讨PAK4在绒毛膜癌中的表达及意义。方法选取2008年5月至2010年12月绒毛膜癌组织标本20例作为实验组,正常早孕(6-12周)绒毛组织标本36例作为对照组,应用免疫组化技术检测上述两组绒毛组织中PAK4的表达情况。结果免疫组化检测结果显示:PAK4蛋白的阳性染色主要定位于细胞滋养层细胞的胞质内;实验组PAK4蛋白的阳性染色较强,阳性表达率为70.00%(14/20),明显高于对照组的阳性表达率36.10%(13/36),差异有统计学意义(χ2=5.914,P=0.015)。结论 PAK4可能在绒毛膜癌的发生发展中起了重要作用。
Objective： To investigate the role of PAK4 in the development of choriocarcinomas.Methods：From May 2008 to December 2010,20 cases of choriocarcinomas in People′s Hospital of Xiantao were selected in this study,36 cases of normal villi tissues were collected as control group.Immunohistochemical staining were performed to detect the expression of PAK4.Results：By Immunohistochemical staining PAK4 were mainly expressed in the cytoplasm.The positive rate of PAK4 expression in choriocarcinomas were 70.00%（14/20）,which was significantly higher than that of control group（36.10%）（χ2=5.914,P=0.015）.Conclusion： Our research suggested that overexpression of the PAK4 protein is associated with the development of choriocarcinomas.
出处
《中国优生与遗传杂志》
2012年第3期19-20,共2页
Chinese Journal of Birth Health & Heredity
