摘要
目的:系统分析白芍总苷(TGP)联用甲氨蝶呤(MTX)治疗类风湿性关节炎(RA)的临床疗效及安全性。方法:计算机检索PubMed、CNKI、CBM全文数据库,以"甲氨蝶呤或白芍总苷和类风湿性关节炎"为检索词;纳入自1979年至2011年10月在国内外公开发表的TGP联用MTX治疗RA的随机对照实验(RCT);采用Cochrance系统评价的方法评价纳入研究的质量,并使用Rev2Man4.2版软件对纳入文献进行Meta分析。结果:共纳入10个RCT,合计患者781例,试验组为428例,对照组为353例。通过选择优势比(OR)以及95%的可信区间(95%CI)比较,治疗12及24周两时点所纳入研究的总有效率试验组均显著优于对照组(P<0.01);并且任意不良反应发生率试验组均低于对照组但差异无统计学意义。结论:TGP联合MTX较单用MTX,对RA治疗早期,在总有效率表现出一定的优势;且能够在一定程度上减少不良反应发生率,起到增效减毒作用。
Objective： To analysis the clinical efficacy and safety of the total glucosides paeony（TGP） combined with methorexate（MTX） in treatment for rheumatoid arthritis（RA）.Methods： With ＂the total glucosides paeony or methorexate and rheumatoid arthritis＂ as search word,to retrieve published articles of domestic and external from PubMed,CNKI and CBM database（1979-2010）.The quality of included studies was assessed according to the criteria recommended Cochrane Collabaoration,Meta-analysis were performed using Rev2Man4.2 software.Results： 10 RCTs involving 781 patients were included,experimental group was 428,control group was 353.Meta-analysis results showed effective rate of experimental group was better than that of control group after 12/24 weeks.There was statistical significance,and the incidence of any adverse drug reactions（ARDs） of experimental group was lower.Conclusions： Therapy of TGP combined with MTX in early treatment of RA was much better than MTX alone in total effective rate,and it also could reduce adverse effects,so they could play a role of efficacy enhancing and toxicity reducing.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第4期1115-1119,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
白芍总苷
甲氨蝶呤
类风湿性关节炎
META分析
随机对照实验
有效率
不良反应
Total glucosides paeony
Methorexate
Rheumatoid arthritis
Meta-analysis
Randomized controlled trial
Effective rate
Adverse effects
