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度洛西汀与文拉法辛治疗伴有躯体疼痛的抑郁症临床对照研究 被引量:18

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摘要 目的观察度洛西汀与文拉法辛在治疗抑郁症同时减轻躯体疼痛症状的疗效和安全性。方法将62例对伴有躯体疼痛症状的抑郁症患者随机分为度洛西汀组(31例)和文拉法辛组(31例),观察8周。用汉密尔顿抑郁量表(HAMD-17)、临床疗效总评量表(CGI)和研究用疼痛量表(MOSPM)在治疗前及治疗后第1周、第2周、第4周、第8周末进行评定。结果经过8周的开放性对照研究,度洛西汀组与文拉法辛组在治疗第1、2、4、8周MOSPM和HAMD-17评分均较治疗前降低(P<0.05,P<0.01)。在8周研究结束,两组HAMD-17、CGI-SI评分差异无统计学意义;度洛西汀组起效更快,在第1周度洛西汀组较文拉法辛组MOSPM评分改变有显著性差异(P<0.05),其余时间比较无统计学差异。两组TESS评分比较无显著性差异(P>0.05)。结论度洛西汀与文拉法辛治疗抑郁症疗效相当,但度洛西汀对于躯体疼痛的减轻更明显。
作者 徐彩霞
出处 《精神医学杂志》 2012年第2期133-135,共3页 Journal of Psychiatry
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共引文献56

同被引文献184

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