1Wu H,G oel V,Ha luska F G. P T EN sig na ling pat hways in melanoma[J].Oncogene,2003,(20):3113-3122.doi:10.1038/sj.onc.1206451.
2Silnpson L,Parsons R. PTEN:life as a tumor suppressor[J].Experimental Cell Research,2001,(01):29-41.
3Meuillet E J,Mahadevan D,Berggeren M. Thioredoxin-l binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding:a mechanism for the functional loss of PTEN's tumor suppressor activity[J].Archives of Biochemistry and Biophysics,2004,(02):123-133.doi:10.1016/j.abb.2004.04.020.
4Hamada K,Sasaki T,Koni P A,et a1. The PTEN / PI3K pathway governs normal vascular development and tumor angiogenesis[J].Genes and Development,2005,(17):2054-2065.
5Mayo L D,Dixon J E,Durden D L. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy[J].Biological Chemistry,2002,(07):5484-5489.
8Yu J,Ni M,Xu J,et a1. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocelular carcinogenesis[J].BMC Cancer,2002,(02):29.
9Li J,Yen C,Liaw D,et a1. PTEN a putative protein tyrosine phosphatase genemutated in human brain,breast,and prostate cancer[J].Science,1997,(5308):1943-1947.doi:10.1126/science.275.5308.1943.
10Myers M P,Stolarev P,Eng C. PTEN the tunrlel suppreason from humanloq23 is a deal specificity phosphatase[J].Pmc Natl Aead Set USA,1997,(01):9052.
二级参考文献30
1Taniyama K, Goodison S, Ito R,et al. PTEN expression is maintained in sporadic colorectal tumours[J]. J Pathol, 2001,194(3):341-348.
2Lilja JF, Wu D, Reynolds RK, et al. Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells[J]. Anticancer Res, 2001,21(3B):1969-1974.
3Li J, Yen C, Liaw D,et al. PTEN a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer[J]. Science, 1997,275:1943-1947.
4Tashiro H, Blazes MS, Wu R, et al . Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies[J].Cancer Res, 1997,57(18):3935-3940.
5Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers[J]. Nat Genet, 1997,15(4):356-362.
6Fumari FB, Huang HJ, Cavenee WK. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells[J].Cancer Res, 1998,58(22): 5002-5008.
7Saga Y, Mizukami H, Takei Y, et al. Suppression of cell migration in ovarian cancer cells mediated by PTEN overexpression. Int J Oncol. 2003,23(4): 1109-1113.
8Nassif NT, Lobo GP, Wu X, et al. PTEN mutations are common in sporadic microsatellite stable colorectal cancer[J]. Oncogene, 2004,23(2):617-628.
9Zhao H, Dupont J, Yakar S, et al. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells[J].Oncogene,2004,23(3): 786-794.
10Li DM, Sun H. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells[J]. Proc Natl Acad Sci USA, 1998,95(26):15406-154111.
3Witzel I I,Koh L F, Perkins N D. Regulation of cyclinD, gene expression [ J ]. Biochem Soc Trans, 2010,38(1):217-222.
4Georgescu MM. PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. Genes Cancer 2010, 1: 1170-1177 [PMID: 21779440 DOI: 10.1177/19476019 11407325].
5Viglietto G, Amodio N, Malanga D, Scrima M, De Marco C. Contribution of PKB/AKT signaling to thyroid cancer. Front Biosci (Landmark Ed) 2011, 16: 1461-1487 [PMID: 21196242 DOI: 10.2741/3799].
6Schulman IH, Zhou MS. Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases. Curr Hypertens Rep 2009, 11:48-55 [PMID: 19146801 DOI: 10.1007/ s11906-009-00100].
7Lee J, Kim MS. The role of GSK3 in glucose homeostasis and the development of insulin resistance. Diabetes Res Clin Pract 2007, 77 Suppl 1:$49-$57 [PMID: 17478001 DOI: 10.1016/ j.diabres.2007.01.033].
8Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Bio12001, 17:615-675 [PMID: 11687500 DOI: 10.1146/annurev.cellbio.17.1.615].
10Sharrard RM, Maitland NJ. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines. Cell Signal 2007, 19:129-138 [PMID: 16842970 DOI: 10.1016/ j.cellsig.2006.05.029].
