摘要
目的:探讨痛风(gout)患者甲状腺激素水平的变化及相关影响因素。方法:选取痛风患者60例作为病例组并分为Ⅰ组[血清尿酸(SUA)≤416μmol/L]和Ⅱ组(SUA>416μmol/L),同期在健康体检中心体检者32例作为对照组,记录两组的一般资料、血液生化指标、甲状腺功能指标等。结果:(1)病例组中甲状腺功能减退症患病率16.7%,对照组3.1%(P<0.05);(2)与对照组相比,Ⅰ、Ⅱ组体质量指数(BMI)、SUA、甘油三酯(TG)、总胆固醇(CHO)、促甲状腺素(TSH)、血清瘦素(leptin)水平较高(P<0.05),游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平较低(P<0.05);(3)在病例组患者中TSH与各指标的相关分析显示,TSH与性别、BMI、SUA、leptin呈显著正相关(r分别为0.332、0.244、0.234、0.579,P均<0.05),与FT4呈显著负相关(r=-0.214,P<0.05)。结论:痛风病人甲状腺功能减退症的患病率增加,且BMI、TG、CHO水平升高,可能与其伴随的代谢综合征导致的leptin水平变化有关。
Objective： To explore the change and influencing factors of thyroid hormone in patients with gout.Methods： 60 patients were elected and were divided into group Ⅰ[serum uric acid（SUA） ≤416 μmol/L] and groupⅡ（SUA416 μmol/L）,Control group including 32 healthy people were elected from Health medical center in the same time.The general information,blood biochemical index,thyroid function index and leptin were recorded.Results ：（1） The prevalence of hypothyroidism was 16.7% in case group and 3.1% in control group（P0.05）;（2） Compared with the control group,body mass index（BMI）,SUA,triglyceride（TG）,total cholesterol（CHO）,low-density lipoprotein（LDL-c）,thyroid stimulating hormone（TSH）,leptin were significantly increased and free thyroxine（FT4）,free triiodothyronine（FT3） were lower in group Ⅰand Ⅱ（P0.05）;（3） The liner regression analysis in case group showed that TSH was positively correlated with gender,BMI,SUA,leptin（r=0.332,0.244,0.234,0.579,both P0.05）,and it was negatively correlated with FT4（r=-0.214 P 0.05）.Conclusion ： The prevalence of hypothyroidism is high in patients with gout,whose BMI,TG,CHO are high,the change of serum leptin level in metabolic syndrome patients is responsible for these results.
出处
《天津医科大学学报》
2012年第1期78-80,共3页
Journal of Tianjin Medical University
基金
天津医科大学科学基金资助项目(2010ky39)
