摘要
目的:探讨氯雷他定致不良反应(ADR)的一般规律和临床特点,为临床合理用药提供参考。方法:报道口服过量氯雷他定致儿童肌张力不全1例。收集1994年1月-2011年12月国、内外公开发行的医药期刊中有关氯雷他定致ADR的病例,共14例,并进行分析、评价。结果:氯雷他定引起的ADR在24h内较为多见,其在年龄、性别、临床表现上均无差别。结论:临床在使用氯雷他定时,应严格掌握适应证、用法用量,患者应在医师或药师指导下使用该药,以确保用药安全。
OBJECTIVE：To explore general regularity and clinical characteristics of adverse drug reactions induced by loratadine,and to provide reference for rational drug use in the clinic.METHODS：1 case of children myodystony induced by overdose loratadine was reported and analyzed.A total of 14 ADR cases induced by loratadine were collected from domestic and foreign pharmaceutical journals from Jan.1994-Dec.2011 and analyzed analyzed.RESULTS：Loratadine-induced ADR mainly appeared within 24 h.There was no difference in age,gender and clinical manifestation.CONCLUSION：We should strictly master indications,usage and dosage in the application of loratadine.Meanwhile,we advise patients to use loratadine under the guidance of doctors and pharmacists to guarantee the safety of drug use.
出处
《中国药房》
CAS
CSCD
2012年第16期1521-1522,共2页
China Pharmacy
关键词
氯雷他定
肌张力不全
不良反应
文献分析
Loratadine
Myodystony
Adverse drug reaction
Literature analysis
