摘要
目的:探讨妊娠期肝内胆汁淤积症(ICP)的围生结局。方法:对成都市妇女儿童中心医院2007年1月至2011年1月住院分娩的500例ICP病例进行回顾性分析,将ICP分为轻度和重度,观察其围生结局;选择正常孕妇300例为对照组。结果:①重度、轻度ICP分别为126、374例,两组和对照组平均孕周分别为35.1±1.2周、37.4±1.6周和39.2±1.9周,早产率分别为96.4%、16.6%和4.1%,差异有统计学意义(P<0.05)。②重度组羊水粪染、胎儿窘迫、新生儿窒息发生率明显高于轻度。③2例围生儿死亡,均为重度病例。结论:对ICP患者进行分度诊断和处理,有助于改善围生儿预后。
Objective： To study the perinatal outcomes of intrahepatic cholestasis of pregnancy （ICP ）. Methods：The clinical data of 500 women with mild and severe ICP from Jan 2007 to Jan 2011 were retro- spectively analyzed and 300 normal cases were as the control group, Perinatal outcomes were observed. Results ：（1）126 cases were diagnosed as severe ICP while 374 cases were as mild ICP. The average gesta- tional weeks of the study groups and control group were 35. 1 ± 1.2, 37. 4 ± 1.6 and 39.2 ± 1.9. The pre- mature delivery rates were 96. 4%, 16. 6% and 4. 1%. There was statistical differences（ P 〈0. 05）. （2）meconium-stained amnionic fluid, fetal distress and neonatal asphyxia rates in the severe ICP group was higher than the mild ICP group. （3）2 cases of perinatal mortality were found, which belonged to severe ICP cases. Conclusions：Graduation diagnosis and treatment of ICP is helpful to improve perinatal prognosis.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2012年第4期282-284,共3页
Journal of Practical Obstetrics and Gynecology
关键词
妊娠期肝内胆汁淤积症
妊娠结局
胎儿窘迫
羊水粪染
新生儿窒息
Intrahepatic cholestasis of pregnancy
Perinatal outcome
Fetal distress
Meconium-stained amniotic fluid
Neonatal asphyxia
