摘要
以6-APA(6-氨基青霉烷酸)为原料,经过苯甲酰化保护,硫的氧化,二苯甲酯保护,7位氨基异构化,开环重排,得到异丙烯基表唑啉。用NBS,溴素分别尝试进行溴代,最终得到两个溴代物异构体,并经过核磁共振氢谱对结构进行了确证。
Starting from 6-APA （6-aminopenieillanic acid）, the isopropenylepioxazoline was synthesized through five main steps：pro- tection by benzoylation, oxidation of sulfur, protection by diphenylmethyl ester, the iso-mefization of 7-amino group, as well as decy- clization and rearrangement. Two brominated isomers were obtained with the use of NBS and bromine, and their structures were testi- fied by 1H-NMR.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2012年第4期650-652,共3页
Chemical Research and Application
关键词
氧头孢中间体
异丙烯基表唑啉
溴代
oxacephem intermediate
isopropenylepioxazoline
bromination
