摘要
支气管哮喘是一种临床上常见的呼吸道疾病,研究发现CD4+T细胞在哮喘的发病过程中起重要作用。Th22细胞是最近发现的一类CD4+T细胞功能亚群之一,其主要效应因子IL-22在炎症性疾病、组织修复、创口愈合及自身免疫性疾病中起重要作用,但其具体机制尚未完全清楚。从Th22的细胞因子来源、生物学特性、分化和调控出发,简要探讨Th22细胞与哮喘之间的可能关系。
Asthma is one of the most common chronic lung diseases in clinical.Recent evidence has shown that CD4＋T cells play a critical role in the occurrence of asthma.Th22 cells were identified recently in CD4＋T cell lineages.As a main effector of Th22 cells,IL-22 has a close association with the development of inflammatory,tissue repair,wound healing and autoimmune diseases,but the specific mechanisms are not fully understood.In this paper,we introduced the origin of effect cytokines,and the biological characteristics,differentiation and regulation of Th22,and then summarized the possible relationship between Th22 cells and asthma.
出处
《生命科学》
CSCD
2012年第4期350-353,共4页
Chinese Bulletin of Life Sciences
基金
三峡大学2011年研究生科研创新基金(2011CX062)
