摘要
目的观察长春西汀辅治急性脑梗死(ACI)的临床疗效。方法将80例ACI患者随机分为治疗组和对照组各40例。对照组给予常规治疗;治疗组在常规治疗基础上给予长春西汀注射液20mg静脉滴注,每天1次。全部患者于治疗14d后评估临床疗效,同时于治疗前和治疗14d后抽血查血液流变学的各项指标(全血黏度、血浆黏度、红细胞聚集指数、纤维蛋白原、血小板聚集率)。结果治疗组总有效率为95.0%显著高于对照组的75.0%,差异有统计学意义(P<0.05)。2组治疗前血液流变学指标比较差异无统计学意义(P>0.05);2组治疗后全血黏度、血浆黏度、红细胞聚集指数、纤维蛋白原及血小板聚集率水平均降低(P<0.05或P<0.01),且治疗组低于对照组(P<0.05)。结论长春西汀辅治ACI安全有效,值得临床推广应用。
Objective To observe the effect of vinpocetine on acute cerebral infarction（ACI）. Methods 80 patients with ACI were randomly divided into treatment group and control group, each of 40 cases. Control group were given usual treat- ment, treatment group were given 20 mg vinpocetine, once daily. Clinical outcomes were taken in all patients 14 days after treat- ment. Blood test were taken before and 14 days after the treatment. Results After the treatment, the total effective rate in treatment group was 95.0% higher than 75.0% in control group（ P 〈 0.05 ）. There was no significant difference in hemorheo- logical parameters of two groups before treatment （P 〉 0.05 ）. After treatment, the whole blood viscosity, plasma viscosity, eryth- rocyte aggregation, fibrinogen and platelet aggregation rate levels were lower than those before the treatment of two groups （P 〈 0.05 or P 〈 0.01 ）, and treatment group were lower than control group （ P 〈 0.05 ）. Conclusion Vinpocetine is a brain protec- tive agent, which is very safe and effective and can be popularized.
出处
《临床合理用药杂志》
2012年第10期5-6,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
长春西汀
脑梗死
急性
血液流变学
Vinpocetine
Cerebral infarction, acute
Hemorheology
