摘要
目的通过对腹腔镜与开腹结直癌手术治疗对照研究的系统分析,评价腹腔镜手术在消化道结直癌领域的应用上对于减少术后并发症的发生是否较占优势。方法通过万方数据库搜索国内十年来开展的腹腔镜与开腹结直癌手术治疗的对照研究,共有12组研究中心的1160例患者的数据纳入进行Meta分析。结果直肠癌亚组分析的比值比(OR)为0.05(95%CI0.37～0.81;P=0.003,Pheterogeneity=0.02),结肠癌亚组分析的OR为0.59(95%CI0.30～1.17;P=0.13,Pheterogeneity=0.97),而将两组数据汇总分析后OR为0.56(95%CI0.40～0.79;P=0.0008,Pheterogeneity=0.14),尽管入选的数据可能因为诸如发表偏倚等而受影响的因素不能完全消除,但这干扰我们得出正确分析结果的影响毕竟有限。结论结直癌手术腹腔镜术式相较传统开放性手术在防止术后并发症的发生方面具有较好的优势。
Objective To evaluate the curative effect and safety of laparoscopic resection（LR）compared with open resection（OR）in treatment of colorectal cancer.Methods From all the databases in China,articles of comparative studies of LR and OR for colorectal cancer which were published in recent ten years were retrieved,and correlated indexes of 12 articles including 1160 patients were extracted for meta-analysis.Results The total postoperative complications in LR group happened less than OR group,OR=0.56（95% CI 0.40-0.79;P=0.0008,Pheterogeneity=0.14）.In the sub-analysis of rectal cancer,similar result was achieved,OR=0.05（95% CI 0.37-0.81;P=0.003,Pheterogeneity=0.02）,however it was not significantly different in the sub-analysis of colon cancer,OR=0.59（95% CI 0.30-1.17;P=0.13,Pheterogeneity=0.97）.Conclusions LR is as safe and effective as OR in the treatment of colorectal cancer,furthermore it takes the advantages of less injury and less postoperative complications.
出处
《中华临床医师杂志（电子版）》
CAS
2012年第3期91-94,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
外科学
腹腔镜
结直肠肿瘤
手术后并发症
META分析
Surgery
Laparoscopes
Colorectal neoplasms
Postoperative complications
Meta-analysis
