摘要
目的:探讨了酒精性肝硬化患者血清内毒素、IL-6、IL-8和PRL水平的变化及临床意义。方法:采血鲎试验、放射免疫分析对31例酒精性肝硬化患者进行了血清内毒素、IL-6、IL-8和PRL的检测,并与35名正常人作比较。结果:酒精性肝硬化患者血清内毒素、IL-6、IL-8和PRL水平均非常显著地高于正常人组(P<0.01),且血清内毒素水平与IL-6、IL-8和PRL水平呈正相关(r=0.4788、0.5126.0.6137,P<0.01)。结论:检测酒精性肝硬化患者血清内毒素、IL-6、IL-8和PRL水平的变化,对该病的诊断、治疗和预后观察均有一定的临床实用价值。
Objective To explore the clinical significance of serum endotoxin, IL-6, IL-8 and PRL levels in patients with alcoho- lic liver cirrhosis. Methods Serum endotoxin（ with limulus test）, serum IL-6, IL-8, PRL（with RIA）levels were determined in 31 pa- tients with alcoholic liver cirrhosis and 35 normal controls. Results The serum endotoxin, IL-6, IL-8, PRL levels were significantly higher than those in controls （ P 〈 0.01 ）. Serum endotoxin levels were positively correlated with IL-6, IL-8, PRL levels （ r = 0. 4788, 0. 5126,0. 6137 ,P 〈 0.01 ）. Conclusion Detection of serum endotoxin, IL-6, IL-8, PRL levels is clinically useful for diagnosis, treat- ment and predicting prognosis in patients with alcoholic liver cirrhosis.
出处
《放射免疫学杂志》
CAS
2012年第2期132-133,共2页
Journal of Radioimmanology
