摘要
目的探讨大剂量盐酸氨溴索静脉注射联合雾化吸人在老年人吸人性肺炎治疗中的应用价值。方法62例老年吸人性肺炎患者分为2组，常规剂量盐酸氨溴索组（常规剂量组）30例，除一般抗生素治疗、雾化吸人等治疗外，每日分2次静脉滴注盐酸氨溴索60mg；大剂量盐酸氨溴索组（大剂量组）32例，每日分3次静脉滴注盐酸氨溴索270mg，其余治疗与常规剂量组相同。观察两组患者的临床症状缓解时间、退热时间、不良反应发生率、平均住院日、病死率和2个月内复发率的差异。结果两组患者在年龄、性别、症状和体征特点、CURB-65评分、肺炎严重指数（PSI）评分、肺叶累及范围、重症肺炎比例上差异均无统计学意义（均P〉0．05）。大剂量组患者临床症状缓解时间、退热时间、平均住院日分别为（3．2±4-0．6）d、（54．2土19．5）h、（12．7±4．1）d，均低于常规剂量组患者（3．8±1．1）d、（66．5±18．4）h、（13．5±3．1）d（t=2．11、2．36、2．04，均P〈0．05）；大剂量组病死率6．3％（2／32）和2个月内复发率3．1％（1／32），与常规剂量组10．0%（3／30）和13．3％（4／30）比较差异无统计学意义（X2=0．01、0．87，均P〉O．05）。两组均无不良反应发生。结论大剂量盐酸氨溴索静脉注射安全有效，对老年吸人性肺炎患者的症状缓解和早期出院具有一定意义。
Objective aspiration pneumonias. To investigate the efficacy of high-dose ambroxol in elderly patients with Methods Totally 62 patients aged 65 years and over with aspiration pneumonia were enrolled into 2 groups： conventional- dose group intravenously given ambroxo[ 60 mg/ d （n= 30） and high-dose group received 270 mg/d （n= 32）. The times of remission and fever disappearance, rate of adverse effects, average duration of hospitalization, rates of mortality and recurrence within 2 months were observed. Results There were no significant differences in clinical characteristics between the two groups. The times of remission and fever disappear ante and average duration of hospitalization were lower in high-dose group than in conventional-dose group [（3.2±0.6） d, （54.2±19.5）h,（12.7±4.1） dvs. （3.8±1.1）d, （66.5±18.4）h,（13.5±3.1）d, t=2. 11, 2.36, 2.04, all P〈0.05]. No differences were found in rates of mortality and recurrence within 2 months between the two groups （6.3%, 3.1% vs. 10.0%, 13.3%, X2=0.01, 0.87, both P〉0.05） . Adverse effects did not appear in the two dose groups. Conclusions High-dose ambroxol is efficient and safe for aspiration pneumonia in elderly patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2012年第4期299-301,共3页
Chinese Journal of Geriatrics
关键词
肺炎
吸人性
氨溴索
Pneumonia, aspiration
Ambroxol
