摘要
目的研究MR弥散加权成像(DWI)对降纤治疗的脑梗死患者中出血性转化(HT)的预测价值。方法 309例接受降纤治疗的脑梗死患者进行DWI及T1WI、T2WI检查后分为出血性转化组(HT组)和非出血性转化组(NHT组);降纤治疗后2周内复查CT或MRI,比较两组DWI特点。结果 309例患者中,14例发生HT(4.5%),DWI可见病灶处信号降低,由高信号变为稍高混杂信号。与NHT组相比,HT组DWI上病灶面积大,最低ADC值及平均ADC值低(P<0.01)。多因素Logistic回归分析结果表明,DWI上病灶体积,病灶最大直径及最低ADC值是脑梗死患者降纤治疗后HT发生的独立危险因素。结论降纤治疗后,脑梗死患者HT发生率较低;DWI可以作为降纤患者HT的一个预测指标。
Objective To investigate the value of diffusion-weighted imaging（DWI） in predicting the hemorrhagic transformation（HT） in patients with acute cerebral infarction undergoing defibrase therapy.Methods The clinical and imaging data of 309 patients with cerebral infarction undergoing defibrase therapy were retrospectively analyzed.All patients received DWI,T1 weight-imaging（T1WI） and T2 weight-imaging（T2WI） examinations.According to CT or MRI results checked within two weeks after admission,the patients were divided into two groups of HT（with HT） and NHT（without HT）.Clinical and DWI features were compared between two groups.ResultsAmong 309 patients,14 cases occurred HT（4.5%） with DWI signal in lesions decreased slightly by the high signal into a mixed signal.Compared with group NHT,the patients in group HT had lower values of minimum ADC and mean ADC and greater lesion volumes on DWI（P〈0.01）.Logistic regression analysis showed that the lesion volumes,lesion diameters and minimum ADC value on DWI were the independent risk factors for HT in patients with cerebral infarction after defibrase therapy.Conclusion The incidence of HT after defibrase therapy in the patients with cerebral infarction is low,in whom DWI may be taken as an indicator for predicting HT.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第7期774-776,F0002,共4页
Jiangsu Medical Journal
基金
南京市医学重点科技发展项目(ZKX6027)
关键词
弥散加权成像
降纤治疗
出血性转化
Diffusion-weighted imaging
Defibrase therapy
Hemorrhagic transformation
