摘要
健康成年人自愿受试者17例,随机分为5组,分别肌注盐酸丁丙诺啡0.03、0.05、0.1、0.2和0.3mg,住院观察。结果表明,该药可使心率减慢,0.3mg组峰作用时可减少12.8%(P<0.05);使收缩血压最大下降幅度在7～10%之间(p<0.05),但舒张压却呈轻度上升趋势;能产生类似于吗啡的呼吸抑制作用;对正常人体温影响不大。上述各项生理参数无重要临床意义。该药可提高辐射热所致基础痛阈和痛耐受(p<0.05),且持续时问在6h以上。正常人用药后可产生典型吗啡样副作用和轻度改变心境作用,包括头晕、嗜睡、恶心、呕吐、松驰、舒适和飘然欲仙等。肝肾功能和血尿常规检查未见异常。本研究认为将盐酸丁丙诺啡控制在0.1至0.3mg成年人使用,便具有明显镇痛作用,而且不会产生严重不良反应。
17 Healthy volunteers were selected and randomized into5 dose groups. Each of them received a single dose of buprenorphine0.03, 0.05, 0. 1, 0 .2 and 0 .3mg by im injection respectively. Results showedthat heart rate was clianged with a maximal decrease of 12.810 (p<0.05)in 0 .3mg group. Systolic blood pressure was dropped with a range of 7-10% (p<0 .05), but diastolic blood pressure appeared with a trend ofminor increace. There was a statistically significant fall in respirationrate, but no significant change was measured in body temperature. In nocase was there any cause for clinic concern and no treatment was requiredfor these respiratory or cardioyascular changes. Studies using thermal stimulation showed that buprenorphine elevatedthe experimental pain threshold and tolerance and the analgesic effect canpersisted more than six hours, The most common side-effects were diz-ziness, drowsiness, nausea and vomiting, and some slight morpine-likemood-altering effects were observed during this trail. Laboratory analysesrevealed no abnormalities. By coming to a conclusion, buprenorphine is apotent analgesic and no severe side-effects may be produced with a doseranges of 0. 1 to 0 .3mg.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1990年第1期37-43,共7页
The Chinese Journal of Clinical Pharmacology
