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环磷酰胺联合糖皮质激素治疗狼疮性肾炎55例临床分析 被引量:3

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摘要 目的:探讨环磷酰胺治疗狼疮性肾炎的临床疗效和安全性。方法:狼疮性肾炎患者110例,随机分为治疗组和对照组各55例,对照组服用泼尼松片,治疗组在对照组基础上使用环磷酰胺冲击疗法,并对两组的效果进行分析对比。结果:经治疗后,对照组总有效率为65.45%,治疗组总有效率为94.55%,两组治疗效果比较差异有统计学意义(P<0.01)。两组治疗后24h尿蛋白、补体(C3、C4)、血肌酐(SCr)与治疗前比较差异有统计学意义(P<0.001);治疗后各项指标治疗组与对照组比较差异有统计学意义(P<0.01)。结论:环磷酰胺联合糖皮质激素是治疗狼疮性肾炎的有效方案,可减少复发,不良反应少。
作者 刘武
机构地区 卢氏县人民医院
出处 《中外医学研究》 2012年第10期27-28,共2页 CHINESE AND FOREIGN MEDICAL RESEARCH
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  • 1Michael W, Matthew J, David J, et al. Mycophenolate mofetil for in- duction therapy of lupusnephritis : a systematic review and meta anal- ysis [ J ]. Clin J Am Soc Nephro,2007, ( 2 ) :968 - 975.
  • 2Kamanamool N, McEvoy M, Attia J, et al. Efficacy and Adverse E- vents of Mycophenolate Mofetil Versus Cyclophosphamide for Induc- tion Therapy of Lupus Nephritis : Systematic Review and Meta-Analy- sis[J]. Medicine,2010,89(4) :227 -235.
  • 3Grootscholten C, Bajema IM, Florquin S, et al. Treatment with cyclo- phosphamide delays the progression of chronic lesions more effective- ly than does treatment with azathioprine plus methylprednisolone in patients with proliferative lupus nephritis[ J ]. Arthritis and Rheuma- tism,2007,56 ( 3 ) :924 - 937.
  • 4Zhang FS,Nie YK,Jin XM, et al. The efficacy and safety of lefluno- mide therapy in lupus nephritis by repeat kidney biopsy [ J ]. Rheu- matolInt, 2009,29 ( 11 ) : 1331 - 1335.
  • 5Miyasaka N, Kawai S, Hashimoto H, et al. Efficacy and safety of ta- crolimus for lupus nephritis:a placebo-controlled double-blind multi- center study [ J ]. Modern rheumatology ,2009,19 (6) :606 - 615.
  • 6Chen W,Tang X, Liu Q, Chen W, et al. Short-term outcomes of in- duction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis : A muhicenter randomized clinical trial [ J ]. Am J Kidney Dis ,2011,57 (2) :235 - 244.
  • 7Lu TY, Ng KP, Cambridge G, et al. A retrospective seven-year analy- sis of the use of B cell depletion therapy in systemic lupus erythema- tosus at University College London Hospital: the first fifty patients [ J]. Arthritis Rheum,2009,61 (4) :482 - 487.
  • 8Elie C, Brocheriou I, Knebelmann B, et al. Rituximab in Severe Lu- pus Nephritis:Early B-Cell Depletion Affects Long-Term Renal Out- come [ J ]. CJASN .2009.4 ( 3 ) : 579 - 587.
  • 9Illei GG, Shirota Y, Yarboro CH,et al. Tocilizumab in systemic lupus erythematosus : data on safety, preliminary efficacy, and impact on cir- culating plasma cells from an open-label phase 1 dosage-escalation study[ J ]. Arthritis and Rheumatism ,2010,62 ( 2 ) :542 - 552.
  • 10Cardiel MH,Tumlin JA, Furie RA, et al. Abetimus sodium for renal flare in systemic lupus erythematosus : Results of a randomized, con- trolled phase III trial[ J]. Arthritis and Rheumatism,2008,58 (8) : 2470 - 2480.

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