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BCAR1/P130CAS与肿瘤相关机制研究进展 被引量：1

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摘要 CAS（Crk-associated substrate）蛋白家族作为细胞信号网络连接位点之一,过去10多年被相继发现,目前明确的有乳腺癌抗雌激素药物耐药蛋白（breast cancer anti-estrogen resist-ance 1,BCAR1）,神经元细胞表达发育下调基因9（NEDD9）,胚胎FYN相关底物（EFS）,CAS蛋白4（CASS4）,其中研究最广泛的是BCAR1。BCAR1又名P130CAS。最初由Reyn-olds等[2]在v-Crk和v-Src转化鸡胚胎细胞中发现,
作者 黄伟 邓波 王如文 蒋耀光
机构地区 第三军医大学大坪医院野战外科研究所/全军胸外科中心肺外科
出处 《重庆医学》 CAS CSCD 北大核心 2012年第10期1009-1011,共3页 Chongqing medicine
基金 重庆市自然科学基金资助项目(CSCT 2011BB5020) 第三军医大学青年人才创新基金资助项目(2010XQN36)
关键词 BCAR1/P130cas CAS 凋亡/失巢调亡 侵袭转移
分类号 R730.2 [医药卫生—肿瘤]
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参考文献28

  • 1Tikhmyanova N,Little JL,Golemis EA.CAS proteins in normal and pathological cell growth control[J].Cell Mol Life Sci,2010,67(7):1025-1048.
  • 2Kanner SB,Reynolds AB,Parsons JT.Tyrosine phospho-rylation of a120-kilodalton pp60src substrate upon epi-dermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-anti-gen-transformed cells[J].Mol Cell Biol,1991,11(2):713-720.
  • 3Sakai R,Iwamatsu A,Hirano N,et al.A novel signaling molecule,p130,forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner[J].EMBO J,1994,13(16):3748-3756.
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二级参考文献16

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重庆医学
2012年 第10期

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