摘要
目的 :研究 5-氟脲嘧啶不同给药方式的药物疗效 ,探讨提高其疗效的可行方案。方法 :以前列腺癌肿瘤细胞系 PC- 3M为研究对象 ,观察 5-氟脲嘧啶对 PC- 3M体外细胞系及裸鼠体内肿瘤生长的抑制作用及其毒副作用。结果 :5-氟脲嘧啶对体外肿瘤生长的抑制作用起效浓度1 μg/ml;小剂量 5-氟脲嘧啶 (2 0 mg/kg)肿瘤内注射给药对裸鼠体内移植瘤的抑瘤率为 1 0 .5% ,体重较对照组无减轻 ;大剂量 5-氟脲嘧啶 (50 mg/kg)肿瘤内注射抑瘤率为 71 % ,体重一过性减轻 ;大剂量 5-氟脲嘧啶 (50 mg/kg)全身用药 ,实验动物体重迅速减轻 ,一周内全部死亡。结论 :高浓度 5-氟脲嘧啶有较好的肿瘤抑制作用 ,肿瘤内注射给药可保证局部 5-氟脲嘧啶的高浓度而全身毒副作用较低 ,对于局部复发的前列腺癌有一定的治疗作用 。
? Objective To find outan effective way to enhance the efficacy of5- Fluorouracil on prostate cancer cell line PC- 3M in vitro and in vivo. Methods Cytotoxicity was examined with MTT assay in vitro. The nude mice were divided into 4 groups:the control group ,the high dose intraperitoneal administration group,the low dose intratumor administration group,the high dose intratumor administration group.The tumor volume and the tumor growth inhibition rate were assayed.Results The maximum noncytotoxic dose for5- FU was0 .1 μg/ml and the50 % inhibitory concentration was1 0 0 μg/ml.The growth inhibition rate of the low dose intratumor administration group was1 0 .5% ,the growth inhibition rate of the high dose intratumor administration group was71 % ,and the high dose intraperitoneal administration group died within 7days. Conclusion High dose 5- FU intraperitoneal administration is an efficient therapy in androgen- independentprostate cancer with few side effects. 〔
出处
《白求恩医科大学学报》
CSCD
2000年第3期255-257,共3页
Journal of Norman Bethune University of Medical Science
基金
吉林省科委资助课题(963001-2)
