摘要
目的 研究月经失调遗传易感性。方法 对某纺织厂 499名新婚女工进行健康调查 ;用PCR 限制性片段长度多态性 (PCR RFLP)检测PON2基因型 ,采用Logistic回归分析评价PON2基因遗传多态性与月经周期过长的关系。结果 在未调整环境因素条件下 ,PON2A148G杂合子基因型有增加月经周期过长危险度的趋势 ,但差异无显著性 ,而A148A纯合子基因型可明显增加月经周期过长危险度(A148G :OR =2 33,95 %CI 0 6 2～ 3 83;A148A :OR =6 15 ,95 %CI 1 86～ 2 0 37)。调整潜在影响因素后 ,A148G杂合子基因型差异无显著性 ,而A148A纯合子基因型仍可明显增加月经周期过长危险度 (A148G :OR =2 45 ,95 %CI0 6 8～ 8 83;A148A :OR =6 2 4,95 %CI 1 91～ 2 0 38)。结论 PON2基因遗传多态性与月经周期过长相关。
Objective To investigate genetic susceptibility to menstrual disorder. Methods Data of 499 female workers were collected in a textile mill. Genotypes of the sample were examined by PCR restriction fragment length polymorphism (PCR RFLP). The PON2 (Paraoxonase) polymorphisms associated with long menstrual cycle were evaluated by logistic regression, with adjustment for the potential confounders. Results The result showed PON2 A148G heterozygote increased the risk of long menstrual cycle, but its OR was not significant statistically. However, A148A homozygote was associated with a significantly increased risk of long menstrual cycle (A148G: OR =2 33,95% CI 0 62～3 83; A148A: OR =6 15, 95% CI 1 86～20 37). After adjusting the potential confounders, both A148G heterozygote and A148A homozygote remained the same significance of their associations with the risk of long menstrual cycle (A148G: OR =2 45, 95% CI 0 68～8 83;A148A: OR =6 24,95% CI 1 91～20 38). Conclusion PON2 polymorphism is associated with the risk of long menstrual cycle.
出处
《安徽医科大学学报》
CAS
2000年第2期125-127,共3页
Acta Universitatis Medicinalis Anhui
