摘要
目的探讨多体素质子磁共振波谱(1H-MRS)在阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UPPP)前后的临床应用价值。方法 20例中重度OSAHS患者行UPPP,术前及术后均行头颅多体素1H-MRS检查。分别记录半卵圆中心区、基底节区各代谢物比值,比较两者间的差异,并观察有无乳酸(Lac)峰出现。结果术后半卵圆中心区NAA/Cr、NAA/Cho(分别为2.422±0.265和1.487±0.168),较术前(2.199±0.143和1.163±0.170)升高,术后Cho/Cr(1.580±0.175)较术前(1.768±0.113)明显下降(P<0.05)。术后基底节区NAA/Cr、NAA/Cho(分别为1.995±0.131和1.673±0.155)较术前(1.932±0.155和1.568±0.141)稍升高,术后Cho/Cr(1.181±0.129)较术前(1.262±0.134)无明显变化(P>0.05)。两组均未检测到Lac峰。结论多体素1H-MRS能敏感显示OSAHS患者UPPP前后脑代谢改变,为临床疗效及预后评估提供客观的影像学依据。
Objective： To investigate the clinical usage of multivoxel ^1H magnetic resonance spectroscopy （^1H-MRS） in patients with obstructive sleep apnea hypopnea syndrome （OSAHS） pre- and post-uvulopalatopharyngoplasty （UPPP）. Materials and Methods： Twenty cases of moderate to severe OSAHS underwent UPPP and performed brain multivoxel ^1H-MRS examinations in pre-and post-operation. The ratios of brain metabolites of centrum ovale and basal ganglia were recorded and analyzed, respectively. Results： In the centrum ovule, the postoperative NAA/Cr and NAA/Cho of 2.422±0.265 and 1.487±0.168 was significantly higher than that of the preoperative （2.199i0. 143 and 1. 163±0.170, P〈0.05）. The postoperative Cho/Cr （1.580±0.175） significantly decreased than that of the preoperative （1.768±0.113, P〈0.05）. In the basal ganglia, postoperative NAA/Cr, NAA/Cho （1.995：±0.131 and 1.673±0.155, respectively） was slightly increased than that of the preoperative （1.932±0.155 and 1.568±0.141）. The the postoperative Cho/Cr of 1.181±0.129 decreased than that of the preoperative （1.262±0.134）, but the difference was not significant （P〉0.05）. Conclusion： Multivoxel^1H-MRS may be useful for brain metabolism in patients with OSAHS pre-and post-UPPP.
出处
《磁共振成像》
CAS
2012年第1期8-11,共4页
Chinese Journal of Magnetic Resonance Imaging
关键词
阻塞性睡眠呼吸暂停低通气综合征
多体素1H-MRS
脑代谢
悬雍垂腭咽成形术
Obstructive sleep apnea hypopnea syndrome
Multivoxel ^1H magneticresonance spectroscopy
Cerebral metabolism
Uvulopalatopharyngoplasty
