摘要
目的:比较鼻咽癌不同调强放射治疗(IMRT)计划的剂量学差异。方法:对16例鼻咽癌患者分别设计5、7、9野均分的IMRT计划,3种计划方式采用同步推量技术,比较3种计划中靶区与危及器官的剂量学差异。结果:靶区剂量覆盖率V95%,5野计划明显劣于7野和9野(P<0.05),7野与9野靶区的最大剂量Dmax、平均剂量Dmean、最小剂量Dmin接近(P>0.05),而在5计划中明显偏小,且与7野与9野之间的差异有统计学意义,P<0.05。另外对靶区适合度指数和均匀性指数而言7野与9野区别不大(P>0.05),均优于5野,P<0.05。各危及器官指标间比较5野的值最小(P<0.05),7野与9野相近(P>0.05),所有指标均低于耐受剂量的限值。BODY:5野与7野、9野比较,V10～V20差异均有统计学意义(P<0.05),而V25和V30相当,P>0.05;7野与9野比较V10～V30差异无统计学意义,P>0.05。结论:无论从临床剂量学要求还是设野原则来看,7野IMRT计划可以作为鼻咽癌IMRT的首选。
OBJECTIVE： To compare the different nasopharyngeal carcinoma intensity-modulated radiation dose treatment（IMRT）plans to learn the difference.METHODS： 16 NPC patients were respectively design 5,7,9 fields IMRT plans,three plans means uses synchronously pushing quantity technology,compares three plans target area,OARs the dose of organs to learn the difference.RESULTS： The target area dose coverage V95%,5 fields plan obviously bad in the wild and 7,9 fields plan（P0.05）,7 and 9 fields plan target the greatest dose Dmax and average dose Dmean,minimum dose Dmin is close（P0.05）,and in 5 fields plan for the small,and obviously 7.9 fields plan,the difference between a statistically significant（P0.05）.In addition to the target area suitable for index and evenness index in the 5 fields plan and 7,9 fields plan is not much different from（P0.05）,are better than 5 fields plan（P0.05）.Each index comparison between organ may OARs the fields minimum value（P0.05）,7 and 9 fields plan are close（P0.05）,all indexes below tolerance doses of limits.BODY： 5 and 7,9 fields plan,comparison in V10-V20 are statistically significant differences between 7 fields plan and 9 fields plan（P0.05）,and V25-V30,quite（P0.05）;7 fields plan and 9 fields plan are more V10-V30 difference was statistically significant（P0.05）.CONCLUSION： No matter from clinical dosimetry requirement or learn fields principle to see,7 fields IMRT plan can be used as the first choice of intensity-modulated radiotherapy（IMRT） of nasopharyngeal carcinoma.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第4期276-279,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
鼻咽肿瘤/放射疗法
治疗计划
剂量学
剂量体积直方图
nasopharyngeal neoplasms/radiation therapy
treatment planning
dosimetry
dose-volume histograms
