摘要
目的 探讨大鼠舌内一氧化氮合酶 (nitricoxidesynthase ,NOS)阳性神经元在伤害性刺激后的形态学变化。方法 用NADPH d组织化学法 ,对大鼠舌内NOS阳性神经元在损伤后的形态学变化进行观察。结果 损伤后舌内NOS阳性神经元胞体明显增大 ,染色加深 ,由其发出的阳性神经纤维明显增粗。在舌体、舌尖段NOS阳性神经元胞体附近出现深染的细颗粒状物质 ,其神经纤维至终末沿途可见到梅花状的NOS阳性结构。在舌根段肌肉组织和腺体周围的NOS阳性神经纤维明显增粗 ,有的纤维内出现了膨体结构。结论 舌内NOS阳性神经元在伤害性刺激时 ,一氧化氮 (nitricoxide,NO)
Objective To explore noxious stimulation induced morphological changes of nitric oxide synthase (NOS)positive neurons in the tongue Methods The histochemical method of reduced nicotinamide adenine dinucleotide phosphate(NADPH) diaphorase activity was used Results NOS positive neuron bodies in the tongue were obviously enlarged,the staining intensity increased and nerve fibers became thicker after injury At the body and tip of the tongue , near the body cells of NOS positive neurons deeply stained fine granular particles were seen , and structures of plum blossom form were seen along the route of the nerve fiber extending all the way to the terminal NOS positive nerve fibers in the striated muscles and around the gland in the tongue root became thicker, and bead structures were seen in some of the fibers Conclusion NOS positive neurons of the tongue, when noxi ously stimulated , are inflicted with pathological changes, which suggest that nitric oxide might play a role in the transmission and control of the message related to pathological lesions
出处
《中华口腔医学杂志》
CSCD
北大核心
2000年第2期144-146,I014,共3页
Chinese Journal of Stomatology
