摘要
目的探讨流式微球分析技术检测人血清中高敏C反应蛋白(Hs-CRP)水平对冠心病诊断的临床价值。方法采用流式微球分析技术检测健康人群和冠心病患者血清中Hs-CRP水平,用统计软件对其临床诊断效能进行评价。结果健康对照人群和患者血清标本中Hs-CRP水平差异有显著性。疾病组内不同病理类型(稳定型心绞痛、不稳定型心绞痛和急性心肌梗死)之间Hs-CRP的检测结果差异均有显著性。根据Hs-CRP的ROC曲线下面积(AUC)进行统计分析,血清Hs-CRP水平用于诊断冠心病有显著意义,诊断灵敏度为87.5%,特异性为82.5%。结论血清中Hs-CRP水平对冠心病的诊断和分层有一定的应用价值,值得在临床上推广。
Objective To explore the diagnostic value of coronary heart disease in serum of Hs-CRP.Methods Hs-CRP in healthy people and patients with coronary artery disease were detected by using cytometric bead array and analyzed the diagnostic performance.Results Compared with the healthy people,the levels of serum Hs-CRP in patients with coronary artery disease there were significant difference,and there are significant differences of the levels of serum Hs-CRP for the patients with coronary artery disease in each type（stable angina,unstable angina,and acute myocardial infarction）.By using statistical analysis for ROC curve（AUC） of Inflammation factors,there were significant difference for according the the levels of serum Hs-CRP to diagnose coronary heart disease.Diagnostic sensitivity was 4.0%,specificity was 2.0%,and can early diagnosis for coronary heart disease.Conclusion The levels of serum Hs-CRP can be helped to clinical diagnosis of coronary heart disease and it is worth to be popularized.
出处
《贵州医药》
CAS
2011年第12期1077-1078,共2页
Guizhou Medical Journal
基金
贵阳市科技局社会发展领域科技攻关项目[(2010筑科农合同字第1-社-35号]
贵州省卫生厅立项资助项目[Gzwlj2009-1-007]资助
