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银屑病患者调节性B细胞检测及意义 被引量：5

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摘要 目的:检测与分析银屑病患者外周血调节性B细胞的数量(即B10细胞),探索B10细胞与银屑病的相关性。方法:收集初发男性银屑病患者并分离其外周血单核细胞(PBMC),以年龄性别相匹配的正常人外周血单个核细胞(PBMC)为对照,体外培养中添加离子霉素、佛波酯、CD40配体等作用5 h,流式细胞术检测CD19+IL-10+细胞比例以分析B10细胞数量,体外刺激48 h分析CD19+IL-10+细胞比例以评估B10前体细胞数量。结果:银屑病患者外周血中B10细胞数量低于正常对照,B10前体数量明显高于正常对照。结论:银屑病患者外周血B10前体细胞增加,B10细胞减少,B10细胞可能对银屑病有保护作用。
作者 万明 高继鑫 张继刚 任婧 周晓燕 李巍 刘玉峰
机构地区 第四军医大学西京医院全军皮肤病研究所
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2012年第4期419-421,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金面上项目(31070793 30972641)
关键词 银屑病 调节性B细胞 B10细胞 流式细胞术
分类号 R392.12 [医药卫生—免疫学]
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参考文献12

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同被引文献40

  • 1陈旭娥,谭志建,岳青,刘厚君,刘志香,李家文.The Expression of Interleukin-23 (p19/p40) and Inteleukin-12 (p35/p40) in Psoriasis Skin[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2006,26(6):750-752. 被引量：3
  • 2Patel RV,Shelling ML,Prodanovich S,et al.Psoriasis and vascular disease-risk factors and outcomes:a systematic reviewof the literature[J].J Gen Intern Med,2011,26(9):1036-1049.
  • 3Shadi M,Amir F.308 nm excimer laser in dermatology[J].J Lasers Med Sci,2014,5(1):8-12.
  • 4Mauri C,Ehrenstein MR.The‘short'history of regulatory B cells[J].Trends Immunol,2008,29(1):34-40.
  • 5Katz S I,Parker D,Turk JL.B-cell suppression of delayed hypersensitivity reactions[J].Nature,1974,251(5475):550-551.
  • 6Wolf SD,Fridrika BD,Hardardottir F,et al.Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice[J].J Exp Med,1996,184(6):2271-2278.
  • 7Mizoguchi A,Mizoguchi E,Smith NR,et al.Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice[J].J Exp Med,1997,186(10):1749-1756.
  • 8Wong FS,Hu C,Xiang Y,et al.To B or not to B-pathogenic and regulatory B cells in autoimmune diabetes[J].curr opin Immunol,2010,22(6):723-731.
  • 9Ma L,Liu B,Jiang ZY,et al.Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis[J].Clin Rheumatol,2014,33(8):187-195.
  • 10Haas KM,Watanabe R,Matsushita T,et al.Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1mice[J].J Immunol,2010,184(9):4789-4800.

引证文献5

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细胞与分子免疫学杂志
2012年 第4期

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