摘要
系统评价心宝丸治疗病态窦房结综合征的临床疗效和安全性。通过计算机检索Cochrane图书馆临床对照试验资料库、MEDLINE、EMbase、中国生物医学文献数据库、美国科学引文索引数据库、中国学术期刊网络出版总库、数字化期刊全文数据库、中文科技期刊数据库,互联网检索在研试验,附加检索相关会议论文集及药厂资料。由2名研究人员独立阅读并交叉核对纳入研究及其资料。结局测量指标:起搏器安装率、动态心电图中的总心搏数、平均心率及治疗有效性、不良反应等。采用Cochrane协作网提供的RevMan 5.0软件进行定性分析。纳入4个随机对照试验(RCT),共包括222名患者。结果显示:3个RCT研究表明心宝丸组治疗后疗效优于对照组,1个RCT显示无明显差异。1个RCT显示holter的平均心率心宝丸组升高显著高于对照组。心宝丸可能对病态窦房结综合征患者的心率升高、症状改善等具有一定疗效,但还有待于设计严格的多中心、大样本随机对照试验来进一步证实。
To evaluate the safety and effects of Xinbao pill in treatment of sick sinus syndrome.Through searching the Cochrane Database of Controlled Trials,MEDLINE,EMbase,China Biological Medicine Database,Science Citation Index database,the United States,China,the total library network publishing academic journals,digital Academic Journal,Chinese Journal of database technology,the internet search in the research test,additional search-related conference proceedings and pharmaceutical information,two researchers independently read data included in the study the in way of cross-checking.Outcome measure indexes included： rate of pacemaker installed,the total cardiac Holter,the average heart rate,efficiency and adverse reactions.Ther qualitative analysis for data was performed by Cochrane Collaboration software Rev Man 5.0.Two hundred and twenty-two patients were included in four randomized controlled trial（RCT）.Three RCT studies showed that effect of Xinbao pill was more obvious than the control group,1 RCT showed no significant difference.1 RCT showed the average heart rate,heart holter in Xinbao pill group was significantly increased.Xinbao pill may increase heart rate in sick sinus syndrome and improve symptoms.However,more rigorous design and large samples can be needed for further confirmation.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第7期286-289,共4页
Chinese Journal of Experimental Traditional Medical Formulae
