摘要
目的 探索阿德福韦酯联合双环醇治疗老年慢性乙型肝炎的疗效和安全性.方法人选96例老年慢性乙型肝炎患者,随机分为两组.在常规治疗的基础上,治疗组,口服阿德福韦酯片（ 10 mg/d）联合双环醇片（25 mg,tid）；对照组口服阿德福韦酯片,10 mg/d；两组疗程均为24周.观察治疗前后血清ALT和AST、病毒学标志物的改变.结果 治疗前与治疗24周末,治疗组ALT分别为（ 208.44±94.22）和（34.47±12.79） U/L,对照组ALT分别为（205.73±96.48）和（44.20±21.96）U/L（组间相比,P＜0.01）；治疗组AST分别为（191.69±84.72）和（37.21±14.31） U/L,对照组AST分别为（189.25±86.17）和（44.20±21.96）U/L（组间相比,P＜0.01）.治疗24周末,治疗组和对照组ALT的复常率分别为76.6％和54.5％,AST的复常率分别为72.3％和50.0％（组间相比均为P＜0.05）；HBV DNA滴度分别下降了（3.1±1.40）lgIU/ml和（2.98±1.17） lgIU/ml（组间相比P＞0.05）.两组不良事件发生率差异无统计学意义.结论 阿德福韦酯联合双环醇治疗老年慢性乙型肝炎的疗效肯定,且安全性好.
Objective To investigate the clinical efficacy and safety of adefovir dipivoxil （ADV） in combination with bicyclol for the treatment of chronic hepatitis B （ CHB ） in seniors.Methods 96 senior patients with CHB were randomly divided into two groups,the treatment group and the control group.On the basis of routine liver protective treatment,patients in the treatment group received ADV （10 mg/d ） and bicyclol tablets（ 25mg,tid.）orally,and those in the control group were orally administrated ADV tablets （10 mg/d） only.The treatment course for both groups was 24 weeks. Serum ALT,AST,and alterations of virological parameters were observed before and after the treatment.Results Before and at the end of the 24 weeks treatment,ALT level for the treatment group was （208.44 ± 94.22） and （34.47 ± 12.79） U/L,and those for the control group was （ 205.73 ± 96.48 ） and （44.20 ± 21.96 ） U/L,respectively （ difference between groups P 〈0.01 ）.At the end of the 24 weeks treatment,ALT normalization rates for the treatment group and the control group were 76.6% and 54.5%,respectively,and AST normalization rates for them were 76.6% and 54.5%,respectively （both differences between groups P 〈 0.05 ） ; HBV DNA loads for the treatment group and the control group were decreased by （3.1 ± 1.40） lgIU/ml and （2.98 ± 1.17） lgIU/ ml,respectively （ difference between groups P 〉 0.05 ）.The incidence rates of adverse events between two groups were not statistically significant.Conclusion It suggested that the treatment of ADV in combination with bicyclol for senior patients with CHB is effective and safe.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2011年第6期453-456,共4页
Chinese Journal of Experimental and Clinical Virology
关键词
老年人保健服务
肝炎
乙型
慢性
双环醇
阿德福韦酯
Health services for the aged
Hepatitis B, chronic
Bicyclol
Adefovir dipivoxil
