摘要
目的调查大剂量甲氨蝶呤治疗急性淋巴细胞白血病所致不良反应的临床特点。方法收集1994年至2010年国内报道关于大剂量甲氨蝶呤治疗急性淋巴细胞白血病不良反应的病例,对甲氨蝶呤的用法用量,不良反应发生的时间和特点进行分析。结果使用大剂量甲氨蝶呤的30例患者中,男性20名,女性8名,不良反应发生以皮肤黏膜损害最多,其次是骨髓抑制、肾功能损害和神经系统损害。结论甲氨蝶呤不良反应的发生应引起临床高度重视,早期发现给予对症治疗,规范亚叶酸钙解救时间和剂量,将不良反应降至最低。
Objective The article investigates the clinical features of the adverse reactions caused by high-dose methotrexate in treating the patients of acute lymphocytic leukemia（ALL）. Methods We collected cases of the adverse reaction reports caused by high-dose methotrexate in treating the patiens of acute ALL from 1994 to 2010 occurred in China, then we analyzed the usage and dosage of methotrexate, the time of the advise reactions occurrence and the characteristics of the adverse reactions. Results methotrexate, including 20 male and 8 female, The results indicate that in the 30 patients treated with high-dose the skin mucosal injury happened most frequently, followed by bone marrow inhibition, renal impairment and neurological damage. Conclusion Adverse events of high does methotrexate should be got more attention in treating the patients of ALL. And when the ADRs symptomatic treatment is very important, for the purpose of minimizing the incidence
出处
《中国药物警戒》
2012年第4期237-239,共3页
Chinese Journal of Pharmacovigilance
关键词
甲氨蝶呤
急性淋巴性白血病
不良反应
methotrexate
acute lymphocytic leukemia
adverse reactions occur, being given timely and of adverse reactions
