摘要
目的探讨维生素类药物致不良反应的一般规律及特点,以提高临床用药的安全性。方法通过检索中国期刊全文数据库1994年1月~2011年8月间相关期刊文章,收集维生素类药物不良反应报道,并进行分类统计、分析。结果维生素类药物所致不良反应共297例,维生素K1所占比例最大（48.8%）,临床表现主要为全身性损害、皮肤及其附件损害,严重者可出现过敏性休克,不良反应多发生在用药30 min内,且静脉给药途径致不良反应所占比例大。结论临床应用维生素类药物应严格掌握用量与疗程,在充分了解该类药物所致不良反应的规律与特点之后,加强临床用药监测,以确保药物治疗全过程安全、合理、有效。
Objective To discuss the characteristics and regularity of adverse drug reaction（ADR） induced by Vitamins,in order to improve the safety of clinical medication.Methods Literatures of ADR induced by Vitamins were retrieved from CNKI during the period of January 1994 to August 2011,and then analyzed statistically.Results Totally 297 cases of ADR induced by Vitamins were collected,of which Vitamin K1 was occupied the largest proportion,accounted for 48.8%.The clinical manifestations were mainly systemic damage and skin and its appendages injuries,and the most severe reaction was anaphylactic shock.Most ADR occurred within 30 min.Intravenous administration was the commonest routes of administration resulted in ADR.Conclusion Clinical staff should grasp the rational dosage and course of Vitamins strictly.Monitoring of the use of drugs should be strengthened to ensure rational,safe and effective use of Vitamins.
出处
《中国医药导报》
CAS
2012年第9期109-111,共3页
China Medical Herald
关键词
维生素
不良反应
文献分析
合理用药
Vitamins
Adverse drug reaction
Literature analysis
Rational use of drug
