摘要
A genome-wide association study recently showed that genetic variants in human leukocyte antigen (HLA)-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus (HBV) in Japanese and Thai individuals and variants in interleukin 28B (IL-28B) have been associated with responses to anti-hepatitis C virus (HCV) treatment. The aim of this study was to investigate whether the HLA-DP loci and IL-28B were associated with different outcomes of chronic HBV infection (CHB) in Chinese subjects. The rs9277535 near HLA-DPB1,rs3077 near HLA-DPA1, and rs12979860 near IL-28B were genotyped by direct sequencing in 185 CHB patients and 193 self-limited hepatitis B virus (SLHBV)-infected subjects who recovered from HBV infection. The rs9277535 near HLA-DPB1 was strongly associated with CHB (P=0.000 018 1, OR=1.905). This association was observed independent of HBV e antigen (HBeAg) status and HBV viral loads in HBeAg-positive CHB patients (P=0.000 4, OR=1.956), in HBeAg-negative CHB patients (P=0.000 9, OR=1.857), and in HBeAg-negative CHB individuals without detectable levels of HBV DNA in serum (P=0.001 1, OR=2.05). The rs3077 near HLA-DPA1 was associated with CHB (P=0.020 6, OR=0.686 5) and HBeAg-positive CHB infection status (P=0.014 3, OR=0.604 7). Meanwhile, a genetic variation of insertion-deletion (INDEL) polymorphism (rs361527, -/ATAAATGTTGA) near HLA-DPA1 was found to be associated with CHB (P=0.030 7, OR=0.702 8) and HBeAg-positive CHB infection status (P=0.023 3, OR=0.619). However,the rs12979860 genotype near IL-28B had no correlation with CHB. This study demonstrated that in the Han Chinese populations, HLA-DP loci, but not IL-28B, were associated with persistence of infection in different outcomes of HBV-infected patients; however, the mechanism needs to be further investigated.
A genome-wide association study recently showed that genetic variants in human leukocyte antigen （HLA）-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus （HBV） in Japanese and Thai individuals and variants in interleukin 28B （IL-28B） have been associated with responses to anti-hepatitis C virus （HCV） treatment. The aim of this study was to investigate whether the HLA-DP loci and IL-28B were associated with different outcomes of chronic HBV infection （CHB） in Chinese subjects. The rs9277535 near HLA-DPB1, rs3077 near HLA-DPA1, and rs12979860 near IL-28B were genotyped by direct sequencing in 185 CHB patients and 193 self-limited hepatitis B virus （SLHBV）-infected subjects who recovered from HBV infection. The rs9277535 near HLA-DPB1 was strongly associated with CHB （P = 0. 000 018 1, OR = 1. 905）. This association was observed independent of HBV e antigen （HBeAg） status and HBV viral loads in HBeAg-positive CHB patients （P = 0.0004, OR = 1. 956）, in HBeAg-negative CHB patients （P = 0. 000 9, OR = 1. 857）, and in HBeAg-negative CHB individuals without detectable levels of HBV DNA in serum （P = 0. 001 1, OR = 2.05）. The rs3077 near HLA-DPA1 was associated with CHB （P = 0. 020 6, OR -- 0. 686 5） and HBeAg-positive CHB infection status （P -- 0. 014 3, OR = 0. 6047）. Meanwhile, a genetic variation of insertion-deletion （INDEL） polymorphism （rs361527, -/ATAAATGTTGA） near HLA-DPA1 was found to be associated with CHB （P = 0. 030 7, OR = 0. 702 8） and HBeAg-positive CHB infection status （P = 0. 023 3, OR = 0. 619）. However, the rs12979860 genotype near IL-28B had no correlation with CHB. This study demonstrated that in the Han Chinese populations, HLA-DP loci, but not IL-28B, were associated with persistence of infection in different outcomes of HBV- infected patients; however, the mechanism needs to be further investigated.
出处
《微生物与感染》
2012年第1期18-27,共10页
Journal of Microbes and Infections
基金
sponsored by the National Key Technologies R&D Program of China during the Eleventh Five-Year Plan Period(2008ZX10002-007 and 2009ZX10004-314)
the National High Technology Research and Development Program(2006AA02A411)
关键词
摘要
编辑部
编辑工作
读者
Hepatitis B virus
Genetic variation
Human leukocyte antigen DPA1
Human leukocyte antigen DPB1
Interleukin-28B
Hepatitis B virus e antigen
Han Chinese population
