摘要
目的比较草酸艾司西酞普兰与米氮平抗抑郁和焦虑的共病作用和不良反应。方法 79例同时符合抑郁症和焦虑障碍诊断标准的门诊和住院患者,HAMD17项总分≥18分≤24分、HAMA总分≥15分≤28分。随机分为草酸艾司西酞普兰组(简称A组)和米氮平组(简称B组),分别口服草酸艾司西酞普兰和米氮平。研究全程5周。结果草酸艾司西酞普兰、米氮平治疗抑郁和焦虑共病疗效相当(P>0.05),其显效率分别为75%、72.2%,且均无严重不良反应,用药安全,耐受性好。结论对具有抑郁和焦虑共病的患者可用草酸艾司西酞普兰。
Objective To compare the effect and side-effect of escitalopram and mirtazapine in treating patients with comorbidity of depression and anxiety.Methods 79 cases,corresponding to the diagnosis standards of depression and anxiety both,their total score of HAMD≥18 and ≤24,that of HAMA≥15 and ≤28,were randomly divided into 2 groups： Escitalopram Group and Mirtazapine Group,and oral administrations of escitalopram and mirtazapine were given respectively;the total course lasted for 5 weeks.Results Escitalopram and mirtazapine were both effective in treating patients with comorbidity of depression and anxiety（P〈0.05）,the obvious effective rates of them were 75% and 72% respectively;both of them led to no serious side-effects and were of good safety and tolerance.Conclusions Escitalopram is effective in treating patients with comorbidity of depression and anxiety.
出处
《西南军医》
2012年第2期222-223,共2页
Journal of Military Surgeon in Southwest China
