细胞因子在类风湿关节炎发病机制中作用的研究进展被引量：35

The progress of study about cytokines on the rheumatoid arthritis nosogenesis

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摘要类风湿关节炎(rheumatoid arthritis,RA)是一种病因尚未明确的以滑膜慢性炎症为主的自身免疫性疾病,近年研究发现,细胞因子网络失衡在RA的发病和进展中发挥着重要作用,该病的加重或好转依赖于炎性细胞因子和调节性细胞因子之间的动态变化。其中TNF-α、IL-1、IL-17、IL-33等在RA滑膜病变中起核心作用,而IL-4、IL-10、TGF-β等细胞因子却可以起到减轻关节损伤的作用。本文将从致炎细胞因子、抑炎细胞因子与RA之间的关系来阐述RA的发病机制。 Rheumatoid Arthritis （RA） is a kind of selfimmune disease with an unknown pathogen, which mainly manifest- ed the chronic inflammation of synovium. Recent studies have found that the cytokine network plays an important role in the onset and progression of RA, the increase or improve of RA depends on the dynamics between inflammatory cytokines and antiinflammatory cytokines. TNF-α, IL-1, IL-17, IL-33 play a bad role, however, IL-4, IL-10, TGF-β can reduce the joint damage. The progress of study about cytokines on the Rheumatoid Arthritis nosogenesis was described in this re view.

作者丁立珉孙万邦

机构地区合肥医学院珠海校区(贵州省免疫学研究生教育创新基地)

出处《中国当代医药》 2012年第7期12-14,共3页 China Modern Medicine

基金贵州省教育厅自然科学研究项目[黔教科(2008032)]

关键词细胞因子类风湿关节炎发病机制致炎因子抑炎因子 Cytokines Rheumatoid arthritis Nosogenesis Inflammatory cytokines Antiinflammatory cytokines

分类号 R593.22 [医药卫生—内科学]

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参考文献24

1Rudwaleit M,Yin Z,Siegert S,et al.Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumor necrosis factor alpha,increase of interleukin 1 0,and predicted by initial concentration of interleukin4[J].Ann Rheum Dis,2000,59(4):311-314.
2Dayer JM.The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis[J].Rheumatology,2003,42(2):3-10.
3Abramson SB,Amin S.Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage[J].Rheumatology,2002,41(9):972-980.
4陈富超,孙万邦,封建凯,杜联峰,黄俊琼,罗军敏,宋明英.重组hIL-10在毕赤酵母X-33的表达及其生物活性鉴定[J].中国免疫学杂志,2011,27(8):691-695. 被引量：17
5Matsuyama Y,Okazaki H,Tamemoto H,et al.Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis[J].J Rheumatol,2010,37(1):18-25.
6林翊萍,徐沪济.细胞因子网络与滑膜炎症[J].细胞与分子免疫学杂志,2010,26(12):1313-1314. 被引量：21
7Fermandes JC,Martel-pelletier J,Pelletier J P.The role of cytokines in osteoarthritis pathophysiology[J].Biorheology,2002,39(12):237-246.
8Strand V,Kavanaugh AF.The role of interleukin-1 in bone resorption in rheumatoid arthritis[J].Rheumatology,2004,43(13):220-226.
9Boyle DL,Rosengren S,Bugbee W,et al.Quantitative biomarker analysis of synovial gene expression by real-time PCR[J].Arthritis Resther,2003,5(6):352-360.
10Honorati MC,Neri S,Catini L,et al.Interleukin-17,a regulator of angiogenic factor release by synovial fibroblasts[J].Osteoarthritis Cartilage,2006,14(4):345-352.

二级参考文献104

1尚鹏,朱平,樊春梅,王彦宏.RANK RANKL和骨保护素在类风湿关节炎患者外周血和滑液中表达的研究[J].中华风湿病学杂志,2005,9(7):417-420. 被引量：14
2井申荣,邹全明,曾韦锟,毛旭虎,刘开云.重组人白细胞介素10在毕赤酵母中的表达及生物学活性测定[J].中华微生物学和免疫学杂志,2005,25(9):773-776. 被引量：5
3廖满林,廖穗波,陈霭平,张曲涛,黄彩燕,陈艳珍,胡祖光.类风湿性关节炎患者IL-1α,IL-1β,IL-17与护骨因子水平检测及临床意义[J].广东医学,2007,28(1):109-110. 被引量：11
4孙杰,李伯安,戚扬,周继文,朱雷,迟淑萍,程云.人IL-10基因的克隆表达及表达产物活性的初步鉴定[J].细胞与分子免疫学杂志,2007,23(3):220-222. 被引量：3
5张曲涛,廖穗波,廖满林,李志平,陈霭平.细胞因子IL-1α、IL-β、IL-17在类风湿性关节炎时的水平分析[J].广州医药,2007,38(1):56-57. 被引量：6
6McInncs IB, Licw FY. Cytokine networks-towards new therapies for rheumatoid arthritis. Nat Clin Pract Rheumatoid Arthritis, 2005, 1: 31-39.
7Bush KA, Farmer KM, Walker JS, et al. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgGIFe fusion protein. Arthritis Rheum, 2002, 46: 802-805.
8Joosten LA, Radstake TR, Lubberts E, et al. Association of interleurleukin-1 beta and tumur necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum, 2003, 48: 339-347.
9Kirkham BW, Lassere MN, Edmonds JP, et al.Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis a two-year prospective study (the damage study cohort). Arthritis Rheum, 2006, 54:1122-1131.
10Cai L, Yin JP, Starovasnik MA, et al. Pathways by which interleukin-17 induces articular cartilage breakdown in vitro and in vivo. Cytokine, 2001, 16: 10-21.