摘要
[目的]了解西安地区健康儿童肠道病毒隐性感染状况，为手足口病防治提供依据。[方法]2010年6～7月采集828份健康儿童肛拭子标本进行肠道病毒病原分析，在2010年9月采集312份1～4岁健康儿童血液标本检测肠道病毒71型IgG抗体。[结果]健康儿童肠道病毒携带率为6．28％（52／828），在1～4岁儿童中肠道病毒71型IgG抗体阳性率为34．62％（108／312）。儿童血清EV71中和抗体阳性率与年龄的关系尤为密切，儿童年龄越小，抗体阳性率越低，随着年龄的增长，儿童感染EV71的抗体阳性率不断增加。[结论]肠道病毒核酸检测不能完全代表健康儿童肠道病毒隐性感染状况，肠道病毒71型IgG抗体阳性率随年龄增长迅速增高。其中≤3岁儿童最为明显，属于HEV71感染引起手足口病流行的易感人群。
[Objective] To understand the status of enterovirus subclinical infection of healthy children in Xi＇an in order to provide the basis for the prevention and control of hand-foot-mouth disease（HFMD）. [Methods] Totally 828 swab samples were collected from healthy children for the analysis of enterovirus during June and July 2010. Totally 312 blood samples were collected from healthy children aged 1~4 years old for the detection of EV71 IgG in September 2010. I[Results] The positive rate of enterovirus in healthy children was 6.28 ~ （52/828） and that of EV71 IgG in healthy children aged 1~4 years old was 34.62% （108/312）. The positive rate of neutralization antibody of serum EV71 in children was closely related to the age. The smaller the children, the lower the positive rate of EV71 IgG. The positive rate of EV71 IgG increased with the age. IConclu- sion] The detection of enteroviral nucleotide can not present the status of enterovirus subclinical infection in healthy children. The positive rate of EV71 IgG increases rapidly with the age. The positive rate of EV71 IgG in children aged less than 3 years old increases most significantly, so they were the susceptible population of HFMD caused by HEV71 infection.
出处
《医学临床研究》
CAS
2012年第2期204-205,208,共3页
Journal of Clinical Research
基金
陕西省科学技术研究发展计划项目（2011K12-82）,西安市卫生局科技项目（J2011028）
