摘要
以N,N'-二环己基碳化二亚胺(DCC)为脱水剂、4-二甲氨基吡啶(DMAP)为催化剂,通过低温缩聚法合成可生物降解并导电的聚5-羧基吲哚(PICA)与聚乙交酯(PGA)的共聚物。合成的产物采用红外光谱仪(FT-IR)、核磁共振氢谱仪(1H NMR)、质谱仪(MS)进行表征。结果表明:产物经25 d降解了41.7%,测得掺杂的共聚物电导率为9.1×10-4S/cm。将乳仓鼠肾细胞(BHK21)黏附于合成的齐聚物膜上,细胞增殖生长效果明显。
A novel degradable electroactive conducting oligomer of poly（indole-5-carboxylic acid）（PICA） and hydroxyl-capped polyglycolide（PGA） was synthesized by low-temperature polycondensation with N,N′-dicyclohexylcarbodiimide（DCC） as dehydrating agent and 4-dimethylaminopyridine（DMAP） as catalyst.The properties and the morphology of the oligomer were characterized by Fourier transform infrared spectrum（FT-IR）,nuclear magnetic resonance spectroscopy（1H NMR） and mass spectrometry（MS）.The oligomer degradation reached 41.7% in weight in the first 25 d.The electrical conductivity of the doped oligomer was measured to be 9.1×10-4 S/cm.To investigate the biocompatibility of the oligomer,baby hamster kidney 21 cells（BHK21） were cultured on oligomer film.Results indicated that the oligomer could support BHK21 cell attachment and proliferation.
出处
《南京工业大学学报（自然科学版）》
CAS
北大核心
2012年第2期100-105,共6页
Journal of Nanjing Tech University(Natural Science Edition)
基金
山东省教育厅科技计划资助项目(J09LB04)
关键词
聚5-羧基吲哚
聚乙交酯
导电聚合物
降解作用
生物相容性
poly （ indole-5-carboxylic acid ）
polyglycolide
conducting polymers
degradation
biocompati-bility
