摘要
目的观察连续性肾脏替代治疗(CRRT)对脓毒症患者细胞免疫功能的影响及其对病情转归的干预作用。方法选择2009年1月～2012年1月收住ICU脓毒症患者52例,随机分为CRRT组(26例)和对照组(26例),两组患者均给予广谱抗生素等治疗,CRRT组在上述基础上连续3天应用CRRT治疗,并观察两组治疗前,治疗后3天、7天的APACHEⅡ评分,检测CD3+,CD4+,CD8+T淋巴细胞百分比及CD4+/CD8+比值。结果两组比较,CRRT组治疗3天后CD3+、CD4+T淋巴细胞百分比和CD4+/CD8+比值已明显升高,治疗7天后APACHEⅡ评分明显下降,差异有统计学意义(P<0.05或P<0.01)。结论 CRRT具有增强脓毒症患者细胞免疫功能,对患者的预后可能有改善作用。
Objective To explore the effects of continuous renal replacement therapy （CRRT） on cell immunity function and outcome in the patients with sepsis. Methods Fifty-two patients with sepsis in the department of intensive care unit （ICU） and acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ） scores between 15 and 30 from January, 2009 to January, 2012. Patients with tumor, organ transplantation, chronic endstage diseases and those who had used immunity inhibitor in recent 3 months or hormones were excluded. The patients were ran- domized into two groups .. CRRT group （n= 26） and control group （n= 26）. Patients in CRRT group were treated with CRRT for 3 days in adddition to the administration of broad-spectrum antibiotics and other therapies to all pa tients. The levels of tlymphocyte subtype were determined on the day before CRRT,3 and 7. At the same time the APACHE U scores were recorded. Results Compared with the control group,in the CRRT group,the levels of CD3 ＋ , CD4＋ and the ratio of CD4＋/CD8＋ had already increased obviously from the third day（all P〈0.05） ;the A- PACHE Ⅱ scores had increased obviously from the 7th day（P〈0.01）. Conclusion CRRT can improve cell im- munity function in the patients with sepsis. CRRT maybe improve the prognosis of sepsis.
出处
《蛇志》
2012年第1期8-10,共3页
Journal of Snake
关键词
连续性肾脏替代治疗
脓毒症
T细胞亚群
continuous renal replacement therapy
sepsis
tlymphocyte subtype
