摘要
目的:了解住院精神分裂症患者苯海索的使用情况,分析其使用的主要因素。方法:回顾性分析符合国际疾病和相关健康问题分类第十版(ICD-10)诊断标准的精神分裂症患者出院病历458份,比较不同抗精神病药物的苯海索使用情况,分析苯海索使用的相关因素。结果:抗精神病药物的苯海索联用率为53.9%(247/458),与苯海索联用最多的药物前4位依次为氟哌啶醇(19/20,95.0%)、齐拉西酮(15/16,93.8%)、帕利哌酮(7/10,70%)、利培酮(52/83,62.7%)。第1代抗精神病药物的苯海索联用率比第2代药物高(72.9%vs.49.6%,P<0.01)。合并用药的苯海索联用率比单一用药高(61.1%vs.50.2%,P<0.05)。女性(OR=1.73,P<0.05)、住院时间长(31～60 d,OR=3.80,P<0.01;>60d,OR=6.96,P<0.01),苯海索联用率越高;与其他精神病药物相比,使用利培酮(OR=2.40,P<0.001)、氟哌啶醇(OR=27.64,P<0.001)、齐拉西酮(OR=19.61,P<0.01)和帕利哌酮(OR=4.40,P<0.01)时更容易联用苯海索。结论:本研究显示,女性、住院时间长,使用利培酮、氟哌啶醇、齐拉西酮和帕利哌酮可能是苯海索使用的主要危险因素。
Objective： To investigate the prescription of trihexyphenidyl among inpatients with schizophrenia and to analyze the main related factors of using trihexyphenidyl. Methods： The data of 458 inpatients＇ discharge records from January 1,2009 to December 31 in Peking University 6^th hospital were analyzed retrospectively. The patients had been diagnosed as schizophrenia according to the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision （ICD-10）. Results： In the sample of patients with antipsychotic drugs, 53.9% was prescribed with trihexyphenidyl, and the top 4 combined antipsychotics were haloperidol （19/20, 95.0% ）, ziprasidone （ 15/16, 93.8% ）, paliperidone （7/10, 70% ）, and risperidone （52/83, 62. 7% ）. The co-pre- scribing rate of trihexyphenidyl in atypical antipsychotics was lower than in typical antipsychotics （49. 6% vs. 72. 9%, P 〈 0. 01 ）, and the rate in combined administration was higher than in single administration（61.1% vs. 50. 2%, P 〈 0. 05）. Females were more likely to be priscribed with trihexyphenidyl combined with antipsychotics than males （56. 5% vs. 47.2%, P 〈 0. 05）. The inpatients who were hospitalized longer were more inclined to high- er co-prescribing rate of trihexyphenidyl in atypical antipsychotics （ OR = 3.80, P 〈 0. 01 ; 〉 60 d： OR = 6. 96, P 〈 0. 01）. The patients who were administrated with haloperidol （OR = 27.64, P 〈 0. 01）, ziprasidone （OR = 19. 61, P 〈 0. 01 ）, paliperidone （ OR = 4. 40, P 〈 0. 01） and risperidone （ OR = 2.40, P 〈 0.01 ） were more apt to use trihexy-phenidyl than other drugs. Conclusion： It suggests that the main risk factors of using trihexyphenidyl are female, longer hospitalisation, using risperidone, haloperidol, ziprasidone and paliperidone.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2012年第3期199-203,共5页
Chinese Mental Health Journal
关键词
精神分裂症
苯海索
药物副作用
相关因素
回顾性研究
schizophrenia
trihexyphenidyl
side effects
related factors
retrospective studies
