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脓毒症微循环功能障碍的评估及其临床意义 被引量：6

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摘要 脓毒症的病理生理过程涉及机体一高度复杂且整合的应答反应,包括各种细胞、炎症介质及凝血系统的激活.1994年Lam C应用活体显微镜对血压稳定的脓毒症大鼠微循环进行在体观察,首次提出脓毒症早期存在微循环变化;1999年正交偏振光谱成像技术（OPS）进入临床应用,证实舌下微循环与内脏器官微循环变化基本一致,使得国内外学者对脓毒症早期存在微循环变化达成共识.近年来越来越多的研究提示,微循环功能障碍是全身炎症反应综合征（SIRS）、脓毒症及其所致多脏器功能障碍综合征（MODS）发生发展中重要的病理生理基础[1-2],早期改善微循环的治疗是保护重要脏器功能的根本措施.本文就脓毒症微循环障碍的发生机制、评估方法及其临床意义做一综述.
作者 于永慧 李敏 王春亭
机构地区 山东省立医院PICU
出处 《中华儿科杂志》 CAS CSCD 北大核心 2012年第3期197-200,共4页 Chinese Journal of Pediatrics
关键词 微循环功能障碍 临床意义 评估方法 脓毒症 多脏器功能障碍综合征 全身炎症反应综合征 微循环变化 病理生理过程
分类号 R459.7 [医药卫生—急诊医学]
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参考文献27

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二级参考文献26

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共引文献9

同被引文献92

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  • 3樊寻梅.儿科感染性休克(脓毒性休克)诊疗推荐方案[J].中华儿科杂志,2006,44(8):596-598. 被引量：208
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引证文献6

二级引证文献31

中华儿科杂志
2012年 第3期

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