摘要
目的研究56例颅脑损伤后凝血功能的变化及临床意义。方法对本院2009年3月至2010年2月收治的56例轻中（B组）、重型（c组）颅脑损伤，既往无肝、肾、血液系统疾病及其他可以引起凝血及纤溶功能改变药物的患者，与27例健康对照组（A组）进行研究，监测其伤后24h内及第3、7天的凝血酶原时间（即，部分凝血活酶时间（AP-IW，凝血酶时间（TT），纤维蛋白原（FIB）及血小板（PLT）的变化。结果伤后24h内，与A、B两组相比，C组患者血浆PT、APTT、TT、FIB和PLT分别为16．43±3．50，29．64±4．54，18．03±1．90，2．32±1．18，141．71±30．89，其中PT、AWT、TT明显延长，差异有显著性fP〈0．05）；FIB和PLT均减低，但无统计学意义。伤后第3天APTT明显升高，差异有显著性。伤后第七天C组患者各项凝血指标均恢复正常，各组之间无显著性差异。结论重型颅脑损伤后可发生凝血功能异常，产生低凝状态。
Objective To study coagulation changes and the clinical characteristics after brain injury. Methods A control group （group A） of 27 healthy individuals was set while 56 brain injury patients were classified into mild injury group （group B） and severe injury group （group C）. The prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （FIB） and platelet count （PLT） were detected in group B and C within 24 hours after trauma, the 3th day, the 7th day after trauma, in comparison with group A. Results Within 24 hours, the PT, APTT, TT, FIB and PLT in group C （GCS≤8） were 16.43±3.50, 29.64±4.54, 18.03±1.90, 2.32±1.18, and 141.71±30.89. Comparing with group A and B, PT, APTT and TT of group C reflected an obvious length （P〈0.05）, with a reduction on FIB and PLT （P〉0.05）. APTT increased at 3th day after trauma with a statistical difference. All the coagulation indexes began to reach nonnal level at 7th day （P〉0.05）. Conclusion Severe brain injury may cause coagulation abnormalities.
出处
《中国急救复苏与灾害医学杂志》
2012年第3期233-235,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
