摘要
目的 :研究胸腺肽微球在大鼠体内的药动学和生物利用度。方法 :用高效液相色谱测定大鼠血中胸腺肽浓度 ,3P87程序计算参数。结果 :胸腺肽微球的药动学参数分别为 :Cmax=2 8.6 0± 9.43μg/ml,tmax=2 10min ,t1/ 2 (β) =144 .40± 19.78min ,AUC0～∞ =76 6 2 .0 3± 70 4.36 μg·min/ml,相对于胶囊剂内容物的生物利用度是 2 38.8%。结论 :大鼠对胸腺肽微球的吸收明显优于胶囊剂内容物。
Purpose:To study on the pharmacokinetics and bioavai lability of oral microspheres of thymopeptide in rat. Methods:Th ymopeptide concentration of rat plasma was determined by HPLC and computerized p harmacokinetics parameters with 3P87 program.Results:The pharmacokin etics parameters of oral microspheres of thymopeptide were:-C-_ max =28.6± 9.43μg/ml,-t-_ max =210min,-t-_ 1/2 (β)=144.40±19.78min,-AUC-_ 0 ～∞ =7 662.03±704.36μg·min/ml,and bioavailability compared with capsule was 238.8%.Conclusion:Absorption of thymopeptide in microspheres has an advantage over that of thymopeptide in capsule in rat.
出处
《中国生化药物杂志》
CAS
CSCD
2000年第1期15-17,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
胸腺肽微球
药代动力学
生物利用度
Thymopeptide microspheres, Pharmacokinetics, Bioavailab ility, Rat
