摘要
目的探讨吉西他滨+米托蒽醌+足叶乙甙(GME)方案诱导化学疗法(化疗)治疗复发难治性急性白血病的疗效。方法 2010年5月-2011年4月对20例复发难治性急性白血病应用GME方案化疗,以了解其有效性、毒副反应。结果随访7个月20例复发难治性白血病经过GME方案诱导化疗1个疗程后总反应率为50%,其中5例完全缓解,4例部分缓解,1例形态学完全缓解而血细胞计数未完全缓解,均无早期死亡患者。结论 GME方案可作为复发难治性急性髓系白血病的一种安全、有效的诱导化疗方案,值得临床尝试。
Objective To explore the efficiency of gemcitabine combined with mitoxantrone and etoposide（GME regimen） for relapsed or refractory acute leukemia.Methods Between May 2010 and April 2011,20 cases of relapsed or refractory acute leukemia were accepted to be treated with GME regimen chemotherapeutically.The efficiency,toxic or side effects were analyzed.Results It showed that the total reaction rate was 50% after a course of inductive GME regimen,including 5 cases of complete remission,4 cases of partial remission and 1 case of morphologically complete remission with blood cell count partial remission.The early mortality rate was zero.Conclusion GME regimen can be a safe and effective try for relapsed or refractory acute leukemia in clinic.
出处
《华西医学》
CAS
2012年第2期168-170,共3页
West China Medical Journal
