摘要
目的:研究情感性精神障碍的电解质改变和验证混合样本的优越性。 方法:对25例情感性精神障碍患者和20例正常对照者测定了红细胞钾、钠和血浆钾、钠、氯。 结果:患者组的情感改变与血钾呈正相关,患者组血钠和血氯的相关性比正常对照组显著为高;患者组中所见的相关性在躁狂组和抑郁组中均消失。 结论:情感性精神障碍的食欲改变可能影响血钾;钠、钾、腺苷三磷酸酶活性降低可能解释患者组的血钠和血氯相关性增高;用混合样本进行生物学相关研究优于用单相样本。
Objective:To study the change in serum and cytosolic electrolytes in patients with affective disorder and demonstrate the advantage of sampling subjects at different phases of illness. Method:Erythrocyte potassium and sodium,serum potassium,sodium and chloride were measured in 25 patients with diagnosis of affective disorder and 20 normal controls. Results:There was significant positive correlation between mood (ranging from depression to mania) and serum potassium in the patient group.There was more significant positive correlation between serum sodium and serum chloride in the patient than control.In contrast to the whole patient group,when taken separately,there was no correlation between mood and serum potassium in 13 patients with manic episode or recovered mania.The same occurred for the 12 patients with depressive episode or recovered depression. Conclusion:Affective disorder may affect serum potassium through appetite change.Decreased sodium,potassium adcnisinc triphosphatase activity may explain a more positive correlation between serum sodium and serum chloride in the patient group than control.Mixed sample was superior in studying biological parameters in mood disorder.
出处
《临床精神医学杂志》
2000年第1期10-11,共2页
Journal of Clinical Psychiatry
