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重组人生长因子药物治疗炎症性肠病的研究进展 被引量:1

Progress of the polypeptide drugs of the recombinant human growth factors for inflammatory bowel disease
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摘要 炎症性肠病(inflammatory bowel disease,IBD)的病因和发病机制尚未完全明确。治疗措施包括水杨酸类制剂、糖皮质激素、免疫抑制剂、抗生素、生物治疗及手术切除等。随着基础免疫病理的研究深入和生物工程技术的发展,近年来出现重组人生长因子多肽药物试用于IBD的治疗。本文对该方面IBD治疗研究进展作一综述。 The etiology and pathgenesis of inflammatory bowel diseases(IBD) have not been fully clarified.Conventional therapies of IBD include five major categories,namely antiinflammatory drugs,corticosteroids,immuno-suppressants,antibiotics,biologic agents and surgical approaches.Alone with the progress of the immune pathology and the development of the biological engineering technology in recent years,the polypeptide drugs of the recombinant human growth factors is used in treatment of IBD.This article will review these new biological agents clinically used for IBD.
作者 章美元 韩真
出处 《胃肠病学和肝病学杂志》 CAS 2012年第3期292-294,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 炎症性肠病 生长因子 治疗 Inflammatory bowel disease Growth factor Therapy
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  • 1Lin-NaLiu Qi-BingMei LiLiu FengZhang Zhen-GuoLiu Zhi-PengWang Ru-TaoWang.Protective effects of Rheum tanguticum polysaccharide against hydrogen peroxide-induced intestinal epithelial cell injury[J].World Journal of Gastroenterology,2005,11(10):1503-1507. 被引量:12
  • 2齐桓,李玉华,郑少斌.以沙门氏菌为载体的口服基因治疗对小鼠肿瘤的作用[J].南方医科大学学报,2006,26(12):1738-1741. 被引量:4
  • 3Rubin J S, Osada H, Finch P W, et al. Purification and characterization of a newly identified growth factor specific for epithelial eells[J]. Proe Natl Aead Sei USA, 1989,86(3) :802-806.
  • 4Draper B W, Stock D W, Kimmel C B. Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development[J]. Development, 2003,130(19) : 4639-4654.
  • 5Igarashi M, Finch P W, Aaronson S A. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor ( FGF-7 ) [J]. Biol Chem, 1998, 273 ( 21 ) : 13230- 13235.
  • 6Chen B L, Arakawa T, Morris C F, et al. Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization[J]. Pharm Res, 1994, 11 (11): 1581-1587.
  • 7Osslund T D,Syed R,Singer E,et al. Correlation between the 1.6A crystal structure and mutational analysis of keratinocyte growth factor [J ]. Protein Sei, 1998, 7 (8) : 1681-1690.
  • 8Blijlevens N, Sonis S. Palifermin (recombinant keratinocyte growth factor-1) : a pleiotropic growth factor with mutiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositisEJ3. Ann Oncol, 2007, 18(5) =817-826.
  • 9Moffa A B, Ethier S P. Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammal/lary epithelial cells[J]. Cell Physiol, 2007,210 (3) :720-731.
  • 10Planz B, Oltean H, Deix T, et al. Effect of keratinocyte growth factor and activin on cell growth in the human prostatic cancer line LNCaP[J]. World J Urol, 2004,22(2):140-144.

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