摘要
目的分析药物性肝病(DILD)的病因、临床特点及预后,提高临床医生对DILD的诊疗水平。方法采用回顾性分析的方法对248例DILD住院患者的用药史、临床表现以及预后等进行研究。结果引起DILD的药物以抗生素类药物(12.1%)、中药(23.0%)、抗结核药物(8.0%)、抗肿瘤药物(7.2%)、免疫抑制剂(14.5%)为常见。临床表现以纳差(62.5%)、乏力(55.1%)、恶心(51.3%)、黄疸(37.2%)、腹痛(18.3%)、瘙痒(12.9%)、皮疹(4.6%)等多见;肝性脑病、腹水、凝血酶原时间、黄疸等因素与患者死亡相关。结论临床医生应重视和加强DILD的预防、诊断和治疗。
Objective To explore the etiology,clinical features and prognosis of drug-induced liver disease（DILD）. Methods A retrospective analysis was taken of DILD in hospitalized for medication history,clinical manifestations. Results The causes of DILD were mainly antibiotics（12.1%）,medicine（23.0%）,anti-TB drugs（8.0%）,anticancer drugs（7.2%）,immunosuppressive agents（14.5%）.The clinical manifestations were mainly anorexia（62.5%）,fatigue（55.1%）,nausea（51.3%）,jaundice（37.2%）,abdominal pain（18.3%）,pruritus（12.9%）,rash（4.6%）. Conclusion Clinicians should pay attention to and strengthen the DILD prevention,diagnosis and treatment.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第3期261-263,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
药物性肝病
预后
临床特点
Drug induced liver disease
Prognosis
Clinical manifestations
