摘要
目的：探讨哇巴因抗体的降压作用及内源性哇巴因与高血压发病的关系。方法：给“一肾一夹（１Ｋ１Ｃ）”、“两肾一夹＋盐（２Ｋ１Ｃ－ｓａｌｔ）”及“两肾一夹（２Ｋ１Ｃ）”肾血管性高血压大鼠随机静注哇巴因抗体、硝普钠、正常免免疫球蛋白（ＩｇＧ）及生理盐水，颈动脉插管观察注射后３小时内大鼠血压的动态变化。结果：哇巴因抗体对“一肾一夹”、“两肾一夹＋盐”型高血压大鼠具有明显的降压作用，而对“两肾一夹”高血压鼠降压作用不明显。正常免免疫球蛋白对各种高血压模型均无降压作用。结论：哇巴因抗体对“一肾一夹”、“两肾一夹＋盐”型高血压大鼠具有降压作用，间接证明了内源性哇巴因可能是高血压的发病因素之一。
Aim:To explore the effects of ouabain antibody on the blood pressure in renovascular hypertensive rats and the relationship between endogenous ouabain (EO) and the development of hypertension. Methods: The rats of 1K1C, 2K1C-salt and 2K1C were injected randomly with ouabain antibody, normal rabbit IgG, normal sodium or sodium nitroprusside. The blood pressure of all rats was recorded for 3 h after administration. Results:The ouabain antibody could significantly decrease the blood pressure of rats with 1K1C and 2K1C-salt (P<0. 01 ), but little change in blood pressure was found in 2K1C rats. The normal rabbit IgG didn't decrease blood pressure in any renovascular hypertensive models. Conclusions: The results showed that ouabain antibody may play a role in decreasing blood pressure and indicated that EO might be one of the pathogenesis factors of hypertension.
出处
《高血压杂志》
CSCD
2000年第1期79-81,共3页
Chinese Journal of Hypertension
基金
国家医药技术创新博士项目!(98-B-07)
陕西省科技研究发展计划项目!(96K12-G8)
